Skip to main content

Table 3 Secondary parameters of paracetamol after intramuscular and oral syrup administration in patients with falciparum malaria

From: Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

Secondary parameters

Intramuscular administration

Oral administration

P value

CMAX (mg/l)

11.4 (10.8–11.8)

8.52 (7.42–9.55)

<0.0001

TMAX (h)

0.689 (fixed)

0.705 (0.577–1.00)

0.442

t1/2 (h)

3.18 (2.67–4.30)

3.03 (2.07–3.53)

0.196

AUC0–12 (h × mg/l)

37.9 (27.5–44.9)

31.6 (27.0–39.3)

0.229

  1. C MAX maximum concentration, T MAX time to reach maximum concentration, t 1/2 terminal half-life, AUC 0–12 area under the concentration–time curve from time 0 to 12 h
  2. Secondary parameters were calculated as the median and range of the empirical Bayes estimates. The P values were calculated with the Wilcoxon matched-pairs signed rank test
Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us