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Table 3 Secondary parameters of paracetamol after intramuscular and oral syrup administration in patients with falciparum malaria

From: Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

Secondary parameters Intramuscular administration Oral administration P value
CMAX (mg/l) 11.4 (10.8–11.8) 8.52 (7.42–9.55) <0.0001
TMAX (h) 0.689 (fixed) 0.705 (0.577–1.00) 0.442
t1/2 (h) 3.18 (2.67–4.30) 3.03 (2.07–3.53) 0.196
AUC0–12 (h × mg/l) 37.9 (27.5–44.9) 31.6 (27.0–39.3) 0.229
  1. C MAX maximum concentration, T MAX time to reach maximum concentration, t 1/2 terminal half-life, AUC 0–12 area under the concentration–time curve from time 0 to 12 h
  2. Secondary parameters were calculated as the median and range of the empirical Bayes estimates. The P values were calculated with the Wilcoxon matched-pairs signed rank test