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Fig. 2 | Malaria Journal

Fig. 2

From: Defining rules of CD8+ T cell expansion against pre-erythrocytic Plasmodium antigens in sporozoite-immunized mice

Fig. 2

Heterologous cross-species immunization increases secondary liver burden compared to homologous immunization in part by circumventing homologously directed antibody responses. a Liver burden at 44 h after single (Py), homologous (Py → Py) or heterologous (Pb → Py) RAS immunizations of BALB/cj mice compared to uninfected animals (none). b Liver burden at 24 h after final immunization of WT C57BL/6 or μMT mice with either single (Pb) or double (Pb → Pb) homologous RAS regimens. c Liver burden at 24 h after homologous RAS immunization of BALB/cj mice mock-treated or treated with anti-CD20 antibodies to deplete B cells. *p < 0.05,**p < 0.01, ***p < 0.001,****p < 0.0001, Students t-test. All doses were 1 × 104 RAS. Plasmodium 18S rRNA content was normalized to the host GAPDH mRNA and differences are expressed in log10 changes in parasite 18S rRNA concentration relative to the single exposure control average

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