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Table 1 var sequences transcribed by parasites infecting a Papua New Guinean cerebral malaria patient

From: Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

var Homologsa, b

Notes

RPKc

Contig bp

Homology bp

E value

% Identity

CIDRα2.4_D3_MAL7P1.55

 

7384

425

131

5.44E−34

84

DBLδ1_D4_ighvar31_CIDRγ9_D5_ighvar35

 

5174

1553

133, 410

2.52E−32, 1E−100

82.7, 79

DBLδ9_D5_PFCLINvar74

 

4369

583

303

1.05E−44

76.2

DBLδ5_D6_Dd2var4

DC5 ELISA protein 2

4227

273

219

1.19E−52

80.4

DBLγ6_D3_DD2var47–DBLγ2_D5_DD2var42

DC8 ELISA protein 4

4130

1807

190, 488

2.57E−58, 6.86E−148

86.3, 85

DBLβ6_D5_igh_var27

 

3562

395

258

3.17E−68

81.8

DBLε1_D6_PFCLINvar76

var1csa

3340

1025

429

0

100

CIDRα3.1_D3_DD2var50

 

2973

550

86.1

3.24E−57

86.1

DBLδ5_D6_Dd2var4

DC5 ELISA protein 2

2891

156

123

7.29E−46

92.7

CIDRβ1_D8_HB3var1

 

2814

650

161

7.44E−41

82.6

CIDRα3.1 pf08–0106–DBLδ5_D5_igh_var30

 

2302

883

167, 310

1.51E−38, 7.32E−68

85.6, 80.6

DBLγ15_D5_PFCLINvar76 (var1csa)

 

2199

246

230

2.56E−117

100

DBLγ17_D4_DD2var43–DBLδ5_D5_HB3var2

DC5

2153

626

192, 250

4.51E−56, 4.23E−31

87.5, 73.6

NTSB3_D1_igh_var31DBLα0.11_D2_AAB60251

ELISA protein 6

2085

189

93, 80

1.03E−19, 1.03E−19

81.7, 85

DBLγ10_D5_HB3var34

DC17,21,22

1994

344

193

2.94E−74

91.7

CIDRβ1_D7_raj116_var11

DC8

1980

606

408

1.98E−60

73.8

DBLβ1_D4_igh_var19

DC8

1935

402

344

1.29E−98

83.7

DBLδ1_D4_HB3var50

 

1911

302

229

3.32E−60

82.1

DBLδ1_D4_IT4var39

 

1894

216

203

2.31E−41

76.4

DBLβ6_D4_igh_var9

 

1883

437

251

3.1E−75

85.3

DBLα0.15_D2_raj116_var34

ELISA protein 6

1871

132

125

6.84E−39

87.2

DBLδ1_D4_IT4var46–DBLγ4_D5_raj116_var11

 

1867

1461

115, 258

4.57E−35, 3.5E−106

87.8, 84.1

DBLα0.1_D2_HB3var30

 

1846

338

215

5.37E−43

82.8

DBLγ6_D5_IT4var32b

DC8

1833

307

178

1.45E−49

83.7

DBLγ13_D5_HB3var21

 

1822

828

402

1.09E−114

90.7

CIDRβ4_dd2var22–DBLβ3_D4_HB3var3

DC5-multi domain contig

1819

1152

707, 339

3.35E−86, 1.34E−59

70.9, 75.2

CIDRα2.9_D3_raj116_var14 –DBLδ1_D6_IT4var32b

 

1741

534

43, 196

1.83E−15, 9.49E−32

100, 76

DBLα0.19_D2_Itvar66-CIDRα2.4_D3_raj116_var29

 

1729

410

96, 279

3.33E−36, 2.73E−56

93.8, 79.2

DBLδ1_D4_igh_var20

 

1724

480

237

5.43E−57

79.7

DBLδ1_D4_IT4var47

 

1714

263

172

3.28E−46

83.7

DBLδ1_D4_igh_var18

 

1696

289

227

2.78E−48

82.8

DBLδ1_D4_PFD1005c

 

1649

191

191

5.39E−36

76.9

DBLβ7_D8_Dd2var4

DC5 ELISA proteins 1 & 3

1644

859

793

1.46E−152

78.6

DBLγ10_D4_PFCLINvar71

ELISA protein 5

1587

511

204

2.3E−71

89.2

DBLβ5_D4_IT4var16-DBLδ1_D4_raj116_var32

 

1579

447

135, 62

5.743E−53, 1.11E−17

93.3, 90.3

DBLδ1_D4_raj116_var29

 

1573

309

297

2.3E−43

73.4

DBLβ12_D4_raj116_var11–DBLγ11_D4_raj116_var17

 

1534

712

215, 178

7.05E−47, 1.45E−36

79.5, 80.3

DBLβ11_D4_IT4var35–DBLγ3_D7_HB3var4

 

1520

931

163, 131

3.27E−65, 3.5E−33

93.3, 83.2

DBLε3_D8_raj116_var29

 

1508

179

60

3.63E−25

100

DBLδ1_D7_IT4var22

 

1454

388

351

6.02E−52

74.1

DBLδ1_D5_igh_var5

 

1438

281

287

1.07E−40

70.5

DBLβ3_D4_AAQ73927–DBLγ4_D5_raj116_var8

 

1428

458

171, 184

8.18E−45, 2.2E−39

83, 79.9

DBLε10_D8_IT4var4

 

1392

442

138

3.35E−43

87.7

DBLδ1_D4_PFCLINvar28 (var2csa)

 

1378

506

138

9.7E−51

91.3

DBLγ8_D7_PFCLINvar76 (var1csa)

 

1377

244

200

1.05E−71

92

DBLγ11_D5_DD2var52–DBLδ1_D4_PFCLINvar36

 

1351

910

322, 84

3.21E−47, 1.12E−27

73.6, 91.7

DBLα1.6_D2_DD2var22

 

1320

111

102

1.7E−26

84.3

DBLα0.15_D2_HB3var18

 

1298

352

306

1.28E−53

77.8

CIDRβ1_D8_IT4var22

 

1297

431

224

9.97E−69

89.7

CIDRα1.5_D3_ighvar30–DBLβ7_D7_PFCLINvar69

EPCR binding

1283

2183

(31, 42, 66), 681

(1.06E−3, 3.7E−3, 1.21E−15), 1.33E−110

(87.1, 90.5, 98.5), 73.6

  1. Shown are the 50 highest-ranked transcripts
  2. aThe domains that were expressed for analysis by ELISA are in italics
  3. bDomain annotation is as per [4]: domain subtype_domain (D) position within the PfEMP1 numbered from the most N terminal DBL/CIDR domain_P. falciparum isolate name var gene name
  4. cThe transcripts are ordered by coverage [reads mapped per kb assembled transcript (rpk)]