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Table 1 var sequences transcribed by parasites infecting a Papua New Guinean cerebral malaria patient

From: Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

var Homologsa, b Notes RPKc Contig bp Homology bp E value % Identity
CIDRα2.4_D3_MAL7P1.55   7384 425 131 5.44E−34 84
DBLδ1_D4_ighvar31_CIDRγ9_D5_ighvar35   5174 1553 133, 410 2.52E−32, 1E−100 82.7, 79
DBLδ9_D5_PFCLINvar74   4369 583 303 1.05E−44 76.2
DBLδ5_D6_Dd2var4 DC5 ELISA protein 2 4227 273 219 1.19E−52 80.4
DBLγ6_D3_DD2var47–DBLγ2_D5_DD2var42 DC8 ELISA protein 4 4130 1807 190, 488 2.57E−58, 6.86E−148 86.3, 85
DBLβ6_D5_igh_var27   3562 395 258 3.17E−68 81.8
DBLε1_D6_PFCLINvar76 var1csa 3340 1025 429 0 100
CIDRα3.1_D3_DD2var50   2973 550 86.1 3.24E−57 86.1
DBLδ5_D6_Dd2var4 DC5 ELISA protein 2 2891 156 123 7.29E−46 92.7
CIDRβ1_D8_HB3var1   2814 650 161 7.44E−41 82.6
CIDRα3.1 pf08–0106–DBLδ5_D5_igh_var30   2302 883 167, 310 1.51E−38, 7.32E−68 85.6, 80.6
DBLγ15_D5_PFCLINvar76 (var1csa)   2199 246 230 2.56E−117 100
DBLγ17_D4_DD2var43–DBLδ5_D5_HB3var2 DC5 2153 626 192, 250 4.51E−56, 4.23E−31 87.5, 73.6
NTSB3_D1_igh_var31DBLα0.11_D2_AAB60251 ELISA protein 6 2085 189 93, 80 1.03E−19, 1.03E−19 81.7, 85
DBLγ10_D5_HB3var34 DC17,21,22 1994 344 193 2.94E−74 91.7
CIDRβ1_D7_raj116_var11 DC8 1980 606 408 1.98E−60 73.8
DBLβ1_D4_igh_var19 DC8 1935 402 344 1.29E−98 83.7
DBLδ1_D4_HB3var50   1911 302 229 3.32E−60 82.1
DBLδ1_D4_IT4var39   1894 216 203 2.31E−41 76.4
DBLβ6_D4_igh_var9   1883 437 251 3.1E−75 85.3
DBLα0.15_D2_raj116_var34 ELISA protein 6 1871 132 125 6.84E−39 87.2
DBLδ1_D4_IT4var46–DBLγ4_D5_raj116_var11   1867 1461 115, 258 4.57E−35, 3.5E−106 87.8, 84.1
DBLα0.1_D2_HB3var30   1846 338 215 5.37E−43 82.8
DBLγ6_D5_IT4var32b DC8 1833 307 178 1.45E−49 83.7
DBLγ13_D5_HB3var21   1822 828 402 1.09E−114 90.7
CIDRβ4_dd2var22–DBLβ3_D4_HB3var3 DC5-multi domain contig 1819 1152 707, 339 3.35E−86, 1.34E−59 70.9, 75.2
CIDRα2.9_D3_raj116_var14 –DBLδ1_D6_IT4var32b   1741 534 43, 196 1.83E−15, 9.49E−32 100, 76
DBLα0.19_D2_Itvar66-CIDRα2.4_D3_raj116_var29   1729 410 96, 279 3.33E−36, 2.73E−56 93.8, 79.2
DBLδ1_D4_igh_var20   1724 480 237 5.43E−57 79.7
DBLδ1_D4_IT4var47   1714 263 172 3.28E−46 83.7
DBLδ1_D4_igh_var18   1696 289 227 2.78E−48 82.8
DBLδ1_D4_PFD1005c   1649 191 191 5.39E−36 76.9
DBLβ7_D8_Dd2var4 DC5 ELISA proteins 1 & 3 1644 859 793 1.46E−152 78.6
DBLγ10_D4_PFCLINvar71 ELISA protein 5 1587 511 204 2.3E−71 89.2
DBLβ5_D4_IT4var16-DBLδ1_D4_raj116_var32   1579 447 135, 62 5.743E−53, 1.11E−17 93.3, 90.3
DBLδ1_D4_raj116_var29   1573 309 297 2.3E−43 73.4
DBLβ12_D4_raj116_var11–DBLγ11_D4_raj116_var17   1534 712 215, 178 7.05E−47, 1.45E−36 79.5, 80.3
DBLβ11_D4_IT4var35–DBLγ3_D7_HB3var4   1520 931 163, 131 3.27E−65, 3.5E−33 93.3, 83.2
DBLε3_D8_raj116_var29   1508 179 60 3.63E−25 100
DBLδ1_D7_IT4var22   1454 388 351 6.02E−52 74.1
DBLδ1_D5_igh_var5   1438 281 287 1.07E−40 70.5
DBLβ3_D4_AAQ73927–DBLγ4_D5_raj116_var8   1428 458 171, 184 8.18E−45, 2.2E−39 83, 79.9
DBLε10_D8_IT4var4   1392 442 138 3.35E−43 87.7
DBLδ1_D4_PFCLINvar28 (var2csa)   1378 506 138 9.7E−51 91.3
DBLγ8_D7_PFCLINvar76 (var1csa)   1377 244 200 1.05E−71 92
DBLγ11_D5_DD2var52–DBLδ1_D4_PFCLINvar36   1351 910 322, 84 3.21E−47, 1.12E−27 73.6, 91.7
DBLα1.6_D2_DD2var22   1320 111 102 1.7E−26 84.3
DBLα0.15_D2_HB3var18   1298 352 306 1.28E−53 77.8
CIDRβ1_D8_IT4var22   1297 431 224 9.97E−69 89.7
CIDRα1.5_D3_ighvar30–DBLβ7_D7_PFCLINvar69 EPCR binding 1283 2183 (31, 42, 66), 681 (1.06E−3, 3.7E−3, 1.21E−15), 1.33E−110 (87.1, 90.5, 98.5), 73.6
  1. Shown are the 50 highest-ranked transcripts
  2. aThe domains that were expressed for analysis by ELISA are in italics
  3. bDomain annotation is as per [4]: domain subtype_domain (D) position within the PfEMP1 numbered from the most N terminal DBL/CIDR domain_P. falciparum isolate name var gene name
  4. cThe transcripts are ordered by coverage [reads mapped per kb assembled transcript (rpk)]