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Table 2 Developmental characteristics and infectivity of PvCSP (VK247)/Pb parasites in Anopheles stephensi mosquitoes

From: Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model

Parasite

Oocysts per midgut (± SEM)

% of midgut infected

Sporozites per salivary gland (± SEM)

% of salivary gland infected

WT-Pb

119.49 (11.64)

96.7

4953 (565)

85.8

PvCSP(VK210)/Pb

131.91 (9.15)

96.7

5415 (555)

84.2

PvCSP(VK247)/Pb

150.14 (10.25)a

94.2

4533 (595)

78.3

  1. Significance was assessed using the Kruskal–Wallis test (oocysts per midgut or sporozoites per salivary gland) or Fisher’s exact probability test (% of midguts or salivary glands infected parasites)
  2. 120 mosquitoes were examined in each experiment
  3. aP < 0.05 (Kruskal–Wallis test) compared with the WT-Pb parasite