Skip to main content

Advertisement

Table 1 McNemar’s χ2 test of haplotype proportions from pre- and post-treatment parasite pairs

From: Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population

  Pre- and post-treatment
Pre Post McNemar’s χ2 (p value) OR (95 % CI)
AMA1   DQRHFDKY Other   
DQRHFDKY 0 0   
Other 2 8 2 (0.16) ND
EBA140   VSTK Other   
VSTK 5 2   
Other 3 5 0.2 (0.65) 0.9 (0.5–1.6)
EBA181   Q K   
Q 5 4   
K 2 2 0.67 (0.41) 1.3 (0.7–2.4)
EBA175   EKEKPISENKKK Other   
EKEKPISENKKK     
Other No data    
EBL-1   QFFFF.VN Other   
QFFFF.VN     
Other No data    
MSP1   KD Other   
KD 7 2   
Other 5 3 1.29 (0.26) 0.8 (0.5–1.2)
MSP3   K1 3D7   
K1 4 2   
3D7 3 0 0.2 (0.65)  0.9 (0.4–1.7) 
MSP6   K1 3D7   
K1 1 2   
3D7 3 9 0.2 (0.65) 0.8 (0.2–2.7)
MSPDBL1   ALTAIKY Other   
ALTAIKY     
Other No data    
MSPDBL2   AHQAIRY Other   
AHQAIRY 2 6   
Other 7 3 0.08 (0.78) 0.9 (0.4–2.0)
Rh1   4HN2QN Other   
4HN2QN 1 2   
Other 1 3 0.33 (0.56) 1.5 (0.4–6.0)
Rh2b   156insQ585del Other   
156insQ585del     
Other No data    
Rh5   HD YH   
HD 13 4   
YH 0 3 4 (0.046) 1.3 (1.0–1.7)
  1. italic value indicates a significant increase in the odds of the Rh5 haplotypes changing compared to staying the same between parasite pairs before and after treatment
  2. Other represents genes with more than 2 high frequency haplotypes, the dominant allele was compared to all other alleles in the population, ND not determined, No data insufficient pairs for the analysis <4