Fig. 1

A phylogenetic tree of all screened genera. This tree was derived from both formal taxonomic classifications (e.g., family, order, class) and informal clades (e.g., rosids, asterids). Bars on the circumference indicate the total number of hits in each genus against the 3D7 and K1 P. falciparum cell lines. Hits were obtained from over 20 different species of the 46 in the entire library that were categorized as endangered or threatened. Genera in which some or all hits were derived from endangered species are marked in red. Larger groups, including many of the orders containing ≥7 genera and sub-order nodes that contained highly productive genera, are labelled