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Table 1 Anti-malarial activity (% activity and EC50, μg/mL) of AHTS fractions from Berberis thunbergii (extract code 80679)

From: Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

Fraction or COMBI Primary (% activity) Secondary (EC50, μg/mL)
μg/mL MAR3D7a MARK1b HEK293c BJd MAR3D7a MARK1b
f8/c9 23.68 43.4 37 2.15 −0.85   
f9/c8 35.75 95.2 80.2 2.52 6.63 8.15 7.57
f10/c7 23.68 97.4 95 8.13 4.91 0.53 0.63
f11/c6 14.39 96.9 96.5 5.29 0 2.02 3.6
f12/c5 8.37 92.8 93.4 7.42 0.7 0.61 0.81
f13/c5 5.57 92 92.4 3.59 0.45 0.39 0.45
f14/c4 5.11 89.9 96 5.05 −0.48 0.86 2.07
f15/c4 7.43 84.9 97.6 6.94 0.56 1.11 10.61
f16/c3 11.14 84.4 93.7 10.1 1.13 0.21 4.77
f17/c2 6.96 95.7 94.6 1.09 1.48 1.66 1.7
f18/c2 5.11 76.9 39 3.12 −0.94   
f19/c1 4.18 35.6 21.2 1.29 0.64   
  1. aChloroquine-sensitive P. falciparum strain
  2. bChloroquine-sensitive P. falciparum strain
  3. cHuman embryonic kidney cells
  4. dHuman foreskin fibroblast