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Table 2 Anti-malarial activity of compounds 1 and 9–13 and fractions from Berberis thunbergii and Eugenia rigida against P. falciparum

From: Diversity-oriented natural product platform identifies plant constituents targeting Plasmodium falciparum

Sample Unit P. falciparum EC50 Sample P. falciparum EC50
3D7 K1 3D7 K1
BT-EtOHa μg/mL NTg NT ER-EtOHh >100 >100
BT-P-Ab μg/mL 0.25 0.291 ER-MeOHi 2 1.37
BT-P-Bc μg/mL 0.23 0.19 ER-Hexj >100 >100
BT-P–Cd μg/mL NT NT ER-Hex-33-52k 1 0.6
BT-P-De μg/mL 10 10 ER-Hex-53-60l 0.7 0.6
7 + 8 f μg/mL 100 0.42 ER-EtOAcm >100 >100
1 μM 0.46 0.44 11 7.7 4.0
9 μM 0.035 0.15 12 NT NT
10 μM NT NT 13 0.3 1.1
  1. a BT-EtOH EtOH extract of B. thunbergii
  2. b BT-P-A acidic CHCl3 fraction of BT
  3. c BT-P-B basic CHCl3 fraction of BT
  4. d BT-P-C EtOAc fraction of BT
  5. e BT-P-D aqueous fraction of BT
  6. fMixture of 7 and 8
  7. g NT not tested
  8. h ER-EtOH EtOH extract of E. rigida
  9. i ER-MeOH MeOH extract of ER
  10. j ER-Hex n-hexane extract of ER
  11. k ER-Hex-33-52 RP-CPTLC fraction of ER
  12. l ER-Hex-53-60 RP-CPTLC fraction ER
  13. m ER-EtOAc EtOAc extract of E. rigida