Fig. 3

Potentiation of anti-plasmodial activity of ART by Cys in Plasmodium chabaudi blood-stage infection (ex vivo/in vivo assay). P. chabaudi parasitized red blood cells (pRBC) were exposed to different drug combinations in vitro for 1-h at 37 °C, washed free of drugs and then used to infect naïve mice. Groups of A/J mice (minimum of 5 mice per group) were infected with 10⁵ drug-treated P. chabaudi pRBCs, and infected mice were monitored for blood parasitaemia (a) at the indicated times post-infection (days 7–10). Drug concentrations are in micromolar (µM). Mortality was recorded (b). Data is representative of three independent experiments and it is expressed as mean ± SD for each group (*p < 0.05)