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Fig. 1 | Malaria Journal

Fig. 1

From: Delayed acquisition of Plasmodium falciparum antigen-specific CD4+ T cell responses in HIV-exposed uninfected Malawian children receiving daily cotrimoxazole prophylaxis

Fig. 1

The proportions of naive and memory CD4+ T cell subsets in HEU and HUU children at different ages. Cells were stained anti CD3 PE, anti CD4 PerCP, anti CD8 APC-H7, anti CD45RA FITC and anti CCR7 APC monoclonal antibodies. a A gate was drawn on CD4 CD8(non T cells) and CD4+ CD8 (CD4+ T cells) populations and plotted on CD45RA FITC against CCR7 APC. Using quadrant statistics, distinct populations of naïve (CD45RA+ CCR7+), central memory (CD45RACCR7+), effector memory (CD45RA CCR7), and terminally differentiated (CD45RA+ CCR7) CD4+ T cells were identified. Median proportions of Naïve CD4+ (b), central memory CD4+ (c), effector memory CD4+ (d), and terminally differentiated CD4+T lymphocytes (e) were determined in peripheral blood of HEU and HUU children at 6, 12 and 18 months. X-axis represents age of children in months. Horizontal bars represent medians

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