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Fig. 2 | Malaria Journal

Fig. 2

From: Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

Fig. 2

Primaquine metabolism by primary human hepatocyte culture pretreated with antidepressants (SSRI or SNRI). Samples were analysed by LC–MS/MS for primaquine disappearance. The 0 and 4-h incubation timepoint measurements for primaquine are shown for the controls and with each tested antidepressant. A relative per cent remaining value of <60 % for primaquine indicated no inhibition of metabolism (green bars) while a value of >60 % indicated inhibition by the indicated antidepressants (red bars). The error shown is from duplicate experiments

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