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Table 1 List of antidepressants utilized in this study

From: Pre-clinical evaluation of CYP 2D6 dependent drug–drug interactions between primaquine and SSRI/SNRI antidepressants

Antidepressant Enzymes involved in biotransformation Enzymes inhibited by antidepressant
Citalopram CYP2C19, CYP2D6, and CYP3A4 CYP2D6 (weak)
Escitalopram CYP2C19, CYP2D6, and CYP3A4 CYP2D6 (weak)
Fluoxetine CYP2D6, CYP2C9, CYP2C19, and CYP3A4 CYP2D6 (strong), CYP2C9 (moderate), CYP2C19, (weak to moderate), CYP3A4 (weak to moderate), CYP1A2 (weak)
Fluvoxamine CYP1A2 and CYP2D6 CYP2D6 (weak), CYP1A2 (strong), CYP2C19 (strong), CYP2C9 (moderate), CYP3A4 (moderate)
Paroxetine CYP2D6 and CYP3A4 CYP2D6 (strong), CYP1A2 (weak), CYP2C9 (weak), CYP2C19 (weak), CYP3A4 (weak)
Sertraline CYP2C9, CYP2C19, CYP2D6, and CYP3A4 CYP2D6 (weak to moderate), CYP1A2 (weak), CYP2C9 (weak), CYP2C19 (weak), CYP3A4 (weak)
Venlafaxine CYP2D6 and CYP3A4 CYP2D6 (weak)
Desvenlafaxine CYP3A4 CYP3A4 (weak)
  1. Shown are the enzymes responsible for metabolism of each antidepressant, and enzymes each that each molecule inhibits. Table was adapted from [22]