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Table 1 Levels of Plasmodium vivax ICB2-5-specific IgM, IgG and IgG subclasses with respect to the analysed genotypes from individuals infected with P. vivax

From: Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)

SNP Gene Genotypes Genotypes (na) Genotypes (nb) IgG (RI) IgG1 (RI) IgG2 (RI) IgG3 (RI) IgG4 (RI) IgM (RI)
rs35593994 CD28 GG/GA/AA 86/80/12 42/39/8 1.02/1.03/1.11 1.11/1.10/0.89 0.92/0.93/0.80 0.76/0.86/0.64 0.77/0.83/0.74 0.66/0.86/1.13c
rs3116496 CD28 TT/TC/CC 118/54/6 60/27/2 1.04/1.02/0.91 1.06/0.98/3.13d 0.91/0.92/0.95 0.82/0.72/0.75 0.82/0.75/0.67 0.83/0.70/0.65
rs733618 CTLA4 TT/TC/CC 135/20/2 72/7/1 1.06/0.89/1.05 1.11/0.97/0.81 0.87/1.18/0.64e 0.80/0.66/0.57 0.80/0.68/0.62 0.82/0.72/1.25
rs11571316 CTLA4 GG/GA/AA 59/75/12 29/39/4 1.04/1.03/0.97 1.17/1.10/0.84 0.96/0.95/0.68 0.74/0.86/0.56 0.73/0.82/0.66 0.81/0.75/0.79
rs5742909 CTLA4 CC/CT/TT 151/27/0 75/14/0 1.15/1.01/– 1.04/1.29/– 0.91/0.93/– 0.80/0.76/– 0.80/0.78/– 0.79/0.78/–
rs231775 CTLA4 AA/AG/GG 75/84/19 40/41/8 1.07/1.00/1.01 0.96/1.22/0.98 0.87/0.98/0.82 0.78/0.82/0.70 0.79/0.79/0.81 0.79/0.75/0.89
rs4675378 ICOS TT/TC/CC 77/73/27 35/38/16 1.00/1.05/1.09 1.08/1.12/0.99 0.86/0.94/0.96 0.73/0.90/0.67 0.80/0.78/0.80 0.80/0.73/0.85
rs1129055 CD86 GG/GA/AA 110/60/8 53/31/5 1.00/1.08/1.15 1.08/1.09/1.06 0.93/0.90/0.93 0.78/0.82/0.70 0.82/0.76/0.70 0.81/0.73/0.90
rs1883832 CD40 CC/CT/TT 135/37/6 65/20/4 1.01/1.06/1.25 1.11/1.03/0.86 0.92/0.95/0.68 0.81/0.77/0.65 0.81/0.75/0.79 0.80/0.69/1.13
rs9514828 BLYS CC/CT/TT 103/62/13 48/35/6 0.99/1.07/1.15 0.99/1.23/0.98 0.91/0.94/0.83 0.82/0.69/1.11 0.76/0.81/0.92 0.73/0.83/0.95
  1. aNumber of individuals evaluated for ICB2-5-specific IgM and total IgG (n = 178)
  2. bNumber of individuals evaluated for ICB2-5-specific IgG subclasses (n = 90)
  3. cSignificant according to the dominant model (p = 0.033)
  4. dSignificant according to the recessive model (p = 0.00004)
  5. eSignificant according to the overdominant model (p = 0.042)