Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)

Table 1 Levels of Plasmodium vivax ICB2-5-specific IgM, IgG and IgG subclasses with respect to the analysed genotypes from individuals infected with P. vivax

SNP	Gene	Genotypes	Genotypes (n^a)	Genotypes (n^b)	IgG (RI)	IgG1 (RI)	IgG2 (RI)	IgG3 (RI)	IgG4 (RI)	IgM (RI)
rs35593994	CD28	GG/GA/AA	86/80/12	42/39/8	1.02/1.03/1.11	1.11/1.10/0.89	0.92/0.93/0.80	0.76/0.86/0.64	0.77/0.83/0.74	0.66/0.86/1.13^c
rs3116496	CD28	TT/TC/CC	118/54/6	60/27/2	1.04/1.02/0.91	1.06/0.98/3.13^d	0.91/0.92/0.95	0.82/0.72/0.75	0.82/0.75/0.67	0.83/0.70/0.65
rs733618	CTLA4	TT/TC/CC	135/20/2	72/7/1	1.06/0.89/1.05	1.11/0.97/0.81	0.87/1.18/0.64^e	0.80/0.66/0.57	0.80/0.68/0.62	0.82/0.72/1.25
rs11571316	CTLA4	GG/GA/AA	59/75/12	29/39/4	1.04/1.03/0.97	1.17/1.10/0.84	0.96/0.95/0.68	0.74/0.86/0.56	0.73/0.82/0.66	0.81/0.75/0.79
rs5742909	CTLA4	CC/CT/TT	151/27/0	75/14/0	1.15/1.01/–	1.04/1.29/–	0.91/0.93/–	0.80/0.76/–	0.80/0.78/–	0.79/0.78/–
rs231775	CTLA4	AA/AG/GG	75/84/19	40/41/8	1.07/1.00/1.01	0.96/1.22/0.98	0.87/0.98/0.82	0.78/0.82/0.70	0.79/0.79/0.81	0.79/0.75/0.89
rs4675378	ICOS	TT/TC/CC	77/73/27	35/38/16	1.00/1.05/1.09	1.08/1.12/0.99	0.86/0.94/0.96	0.73/0.90/0.67	0.80/0.78/0.80	0.80/0.73/0.85
rs1129055	CD86	GG/GA/AA	110/60/8	53/31/5	1.00/1.08/1.15	1.08/1.09/1.06	0.93/0.90/0.93	0.78/0.82/0.70	0.82/0.76/0.70	0.81/0.73/0.90
rs1883832	CD40	CC/CT/TT	135/37/6	65/20/4	1.01/1.06/1.25	1.11/1.03/0.86	0.92/0.95/0.68	0.81/0.77/0.65	0.81/0.75/0.79	0.80/0.69/1.13
rs9514828	BLYS	CC/CT/TT	103/62/13	48/35/6	0.99/1.07/1.15	0.99/1.23/0.98	0.91/0.94/0.83	0.82/0.69/1.11	0.76/0.81/0.92	0.73/0.83/0.95

^aNumber of individuals evaluated for ICB2-5-specific IgM and total IgG (n = 178)
^bNumber of individuals evaluated for ICB2-5-specific IgG subclasses (n = 90)
^cSignificant according to the dominant model (p = 0.033)
^dSignificant according to the recessive model (p = 0.00004)
^eSignificant according to the overdominant model (p = 0.042)

ISSN: 1475-2875