|
Block
|
Haplotype
|
Frequency
|
IgG
|
IgG1
|
IgG2
|
IgG3
|
IgG4
|
IgM
|
|---|
|
∆%
|
p
|
∆%
|
p
|
∆%
|
p
|
∆%
|
p
|
∆%
|
p
|
∆%
|
p
|
|---|
|
Block 1
|
G-T
|
0.522
|
Reference
| | | | | | | | | | | |
|
A-T
|
0.292
|
2 (−9; 13)
|
0.72
|
−3 (−27; 21)
|
0.80
|
−3 (−16; 9)
|
0.61
|
0 (−15; 14)
|
0.95
|
0 (−10; 10)
|
0.99
|
20 (2; 38)
|
0.027
|
|
G-C
|
0.185
|
−3 (−16; 9)
|
0.59
|
21 (−9; 51)
|
0.17
|
0 (−15; 16)
|
0.96
|
−8 (−27; 10)
|
0.38
|
−7 (−19; 5)
|
0.26
|
−6 (−27; 15)
|
0.58
|
|
Block 2
|
T-G-C
|
0.518
|
Reference
| | | | | | | | | | | |
|
T-A-C
|
0.330
|
−2 (−14; 10)
|
0.72
|
−4 (−32; 25)
|
0.81
|
−9 (−23; 5)
|
0.21
|
2 (−16; 19)
|
0.85
|
3 (−9; 16)
|
0.59
|
−7 (−28; 13)
|
0.48
|
|
T-G-T
|
0.076
|
12 (−7; 31)
|
0.22
|
49 (−23; 121)
|
0.18
|
3 (−21; 27)
|
0.83
|
−4 (−34; 25)
|
0.77
|
−3 (−23; 17)
|
0.77
|
−3 (−34; 27)
|
0.84
|
|
C-G-C
|
0.063
|
−17 (−38; 11)
|
0.27
|
−10 (−70; 51)
|
0.75
|
−14 (−44; 17)
|
0.38
|
−14 (−52; 23)
|
0.45
|
−11 (−36; 14)
|
0.38
|
−23 (−54; 9)
|
0.16
|
- The effects of each haplotype are relative to the most frequent haplotype, which was used as a reference. ∆% indicates changes relative to the antibody levels compared to reference haplotypes, with 95 % confidence intervals. Block 1 refers to the SNPs rs35593994 and rs3116496, and block 2 refers to rs733618, rs11571316 and rs5742909
