Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)

Table 2 Haplotype frequencies and their association with levels of ICB2-5-specific antibodies

Block	Haplotype	Frequency	IgG		IgG1		IgG2		IgG3		IgG4		IgM
Block	Haplotype	Frequency	∆%	p	∆%	p	∆%	p	∆%	p	∆%	p	∆%	p
Block 1	G-T	0.522	Reference
	A-T	0.292	2 (−9; 13)	0.72	−3 (−27; 21)	0.80	−3 (−16; 9)	0.61	0 (−15; 14)	0.95	0 (−10; 10)	0.99	20 (2; 38)	0.027
	G-C	0.185	−3 (−16; 9)	0.59	21 (−9; 51)	0.17	0 (−15; 16)	0.96	−8 (−27; 10)	0.38	−7 (−19; 5)	0.26	−6 (−27; 15)	0.58
Block 2	T-G-C	0.518	Reference
	T-A-C	0.330	−2 (−14; 10)	0.72	−4 (−32; 25)	0.81	−9 (−23; 5)	0.21	2 (−16; 19)	0.85	3 (−9; 16)	0.59	−7 (−28; 13)	0.48
	T-G-T	0.076	12 (−7; 31)	0.22	49 (−23; 121)	0.18	3 (−21; 27)	0.83	−4 (−34; 25)	0.77	−3 (−23; 17)	0.77	−3 (−34; 27)	0.84
	C-G-C	0.063	−17 (−38; 11)	0.27	−10 (−70; 51)	0.75	−14 (−44; 17)	0.38	−14 (−52; 23)	0.45	−11 (−36; 14)	0.38	−23 (−54; 9)	0.16

The effects of each haplotype are relative to the most frequent haplotype, which was used as a reference. ∆% indicates changes relative to the antibody levels compared to reference haplotypes, with 95 % confidence intervals. Block 1 refers to the SNPs rs35593994 and rs3116496, and block 2 refers to rs733618, rs11571316 and rs5742909

ISSN: 1475-2875