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Table 2 Haplotype frequencies and their association with levels of ICB2-5-specific antibodies

From: Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)

Block Haplotype Frequency IgG IgG1 IgG2 IgG3 IgG4 IgM
∆% p ∆% p ∆% p ∆% p ∆% p ∆% p
Block 1 G-T 0.522 Reference            
A-T 0.292 2 (−9; 13) 0.72 −3 (−27; 21) 0.80 −3 (−16; 9) 0.61 0 (−15; 14) 0.95 0 (−10; 10) 0.99 20 (2; 38) 0.027
G-C 0.185 −3 (−16; 9) 0.59 21 (−9; 51) 0.17 0 (−15; 16) 0.96 −8 (−27; 10) 0.38 −7 (−19; 5) 0.26 −6 (−27; 15) 0.58
Block 2 T-G-C 0.518 Reference            
T-A-C 0.330 −2 (−14; 10) 0.72 −4 (−32; 25) 0.81 −9 (−23; 5) 0.21 2 (−16; 19) 0.85 3 (−9; 16) 0.59 −7 (−28; 13) 0.48
T-G-T 0.076 12 (−7; 31) 0.22 49 (−23; 121) 0.18 3 (−21; 27) 0.83 −4 (−34; 25) 0.77 −3 (−23; 17) 0.77 −3 (−34; 27) 0.84
C-G-C 0.063 −17 (−38; 11) 0.27 −10 (−70; 51) 0.75 −14 (−44; 17) 0.38 −14 (−52; 23) 0.45 −11 (−36; 14) 0.38 −23 (−54; 9) 0.16
  1. The effects of each haplotype are relative to the most frequent haplotype, which was used as a reference. ∆% indicates changes relative to the antibody levels compared to reference haplotypes, with 95 % confidence intervals. Block 1 refers to the SNPs rs35593994 and rs3116496, and block 2 refers to rs733618, rs11571316 and rs5742909