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Table 2 Clinical pathways for adult and paediatric cases during the study periods (Period 1: 2000–2003, Period 2: 2004–2008, Period 3: 2009–2013)

From: Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

  Period 1 Period 2 Period 3 p value Period 2 vs Period 1 Period 3 vs Period 1
n (%) n (%) n (%) Difference (CI 95 %) Difference (CI 95 %)
Adulta n = 5185 n = 5159 n = 4643    
 Overall hospitalization 2971 (57) 2729 (53) 2335 (50) <10−10 −4 (−6; −2) −7 (−9; −5)
 Medicine ward 2230 (48) 1578 (38) 1318 (34) <10−15 −10 (−13; −9) −15 (−17; −13)
 MW length of stay (mean ± SD) (days) 3.9 (4.0) 4.1 (4.5) 4.2 (3.6) 0.08 0.2 (−0.4; 0.09) 0.3 (0.05; 0.5)
 ICU 174 (4) 181 (4) 303 (8) <10−7 0 (0; 1) 4 (3; 5)
 ICU length of stay (mean ± SD) (days) 5.7 (7.1) 5.3 (8.3) 3.3 (3.5) <10−4 −0.4 (−1.2; 2.0) −2.4 (−3.3; −1.4)
 Proportion of ICU/total admissions (%) 7.2 10.3 18.7 <10−15 3.1 (2.8; 3.4) 11.5 (11; 12)
 Ambulatory care 2214 (43) 2430 (47) 2308 (50) 4.4.10−11 4 (2; 6) 7 (5; 9)
Childrena n = 1891 n = 1189 n = 847    
 Overall hospitalization 1481 (78) 988 (83) 641 (76) 0.20 5 (2; 8) −2 (−6; 1)
 Medicine ward 1185 (74) 676 (74) 477 (67) 0.06 0 (−3; 4) −7 (−11; −3)
 MW length of stay (mean ± SD) (days) 2.7 (2.0) 2.5 (1.9) 2.6 (2.0) 0.08 −0.2 (−0.4; −0.03) −0.1 (−0.3; 0.12)
 ICU 14 (1) 40 (4) 30 (4) <10−9 3 (2; 5) 3 (2; 5)
 ICU length of stay (mean ± SD) (days) 2.5 (1.5) 2.1 (1.6) 4.6 (7.9) 0.10 −0.4(−1.4; 0.5) 2.1 (−2.2; 6.4)
 Proportion of ICU/total admissions (%) 1.2 5.7 5.9 <10−8 4.5 (3.9; 5.2) 4.7 (4.0; 5.4)
 Ambulatory care 410 (22) 201 (17) 206 (24) 0.20 −5 (−8; −2) 2 (−1; 6)
  1. aThere were 2251 and 688 missing values for adult and paediatric cases, respectively