Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

Table 3 Mortality by study period and type of care pathways with main characteristics (type of Plasmodium and severity) (Period 1: 2000–2003, Period 2: 2004–2008, Period 3: 2009–2013)

	Period 1	Period 2	Period 3	p value	Period 2 vs Period 1	Period 3 vs Period 1
	n (%)	n (%)	n (%)	p value	Difference (CI 95 %))	Difference (CI 95 %)
Adults^a	n = 6482	n = 5514	n = 4989
Overall mortality	24 (0.37)	16 (0.29)	14 (0.28)	0.35	−0.08 % (−0.3; 0.13)	−0.09 % (−0.32; 0.12)
P. falciparum	22 (0.34)	16 (0.29)	14 (0.28)	0.50
Severity–French criteria	19 (0.29)	11 (0.2)	14 (0.28)	0.50
Severity–clinical classification	21 (0.32)	15 (0.27)	14 (0.28)	0.50
Medicine ward	2 (0.09)	1 (0.06)	2 (0.15)	0.87
ICU	14 (8.5)	10 (5.52)	12 (3.96)	0.09
Ambulatory care	1 (0.05)	0 (0)	0 (0)	0.13
Children^b	n = 2066	n = 1308	n = 895
Overall mortality	2 (0.1)	0 (0)	1 (0.11)	0.52	−0.1 % (−0.47; 0.1)	(0.01 % (−0.5; 0.29)
P. falciparum	2 (0.1)	0 (0)	0 (0)	0.33
Severity–French criteria	0 (0)	0 (0)	1 (0.11)	0.33
Severity–clinical classification	1 (0.5)	0 (0)	1 (1.1)	0.33
Medicine ward	0 (0)	0 (0)	0 (0)
ICU	2 (14.9)	0 (0)	0 (0)	0.006
Ambulatory care	0 (0)	0 (0)	0 (0)

Data are number (%)
^aFor five dead adults, the type of pathway was missing. Among hospitalized adults, the type of hospitalization was missing for seven adults
^bThe third dead child was hospitalized but the type of hospitalization was missing

ISSN: 1475-2875