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Table 3 Mortality by study period and type of care pathways with main characteristics (type of Plasmodium and severity) (Period 1: 2000–2003, Period 2: 2004–2008, Period 3: 2009–2013)

From: Hospitalization and ambulatory care in imported-malaria: evaluation of trends and impact on mortality. A prospective multicentric 14-year observational study

  Period 1 Period 2 Period 3 p value Period 2 vs Period 1 Period 3 vs Period 1
n (%) n (%) n (%) Difference (CI 95 %)) Difference (CI 95 %)
Adultsa n = 6482 n = 5514 n = 4989    
 Overall mortality 24 (0.37) 16 (0.29) 14 (0.28) 0.35 −0.08 % (−0.3; 0.13) −0.09 % (−0.32; 0.12)
 P. falciparum 22 (0.34) 16 (0.29) 14 (0.28) 0.50   
 Severity–French criteria 19 (0.29) 11 (0.2) 14 (0.28) 0.50   
 Severity–clinical classification 21 (0.32) 15 (0.27) 14 (0.28) 0.50   
 Medicine ward 2 (0.09) 1 (0.06) 2 (0.15) 0.87   
 ICU 14 (8.5) 10 (5.52) 12 (3.96) 0.09   
 Ambulatory care 1 (0.05) 0 (0) 0 (0) 0.13   
Childrenb n = 2066 n = 1308 n = 895    
 Overall mortality 2 (0.1) 0 (0) 1 (0.11) 0.52 −0.1 % (−0.47; 0.1) (0.01 % (−0.5; 0.29)
 P. falciparum 2 (0.1) 0 (0) 0 (0) 0.33   
 Severity–French criteria 0 (0) 0 (0) 1 (0.11) 0.33   
 Severity–clinical classification 1 (0.5) 0 (0) 1 (1.1) 0.33   
 Medicine ward 0 (0) 0 (0) 0 (0)    
 ICU 2 (14.9) 0 (0) 0 (0) 0.006   
 Ambulatory care 0 (0) 0 (0) 0 (0)    
  1. Data are number (%)
  2. aFor five dead adults, the type of pathway was missing. Among hospitalized adults, the type of hospitalization was missing for seven adults
  3. bThe third dead child was hospitalized but the type of hospitalization was missing