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Table 3 Prevalence of G6PD deficiency among children in Hodeidah according to the cut-off activities used to determine the enzyme deficiency

From: Glucose-6-phosphate dehydrogenase deficiency among Yemeni children residing in malaria-endemic areas of Hodeidah governorate and evaluation of a rapid diagnostic test for its detection

G6PD activity cut-offa N Prevalence of G6PD deficiency % (95 % CI)
≤10 % (≤0.5 U/gHb) ≤20 % (≤1.0 U/gHb) ≤30 % (≤1.5 U/gHb) ≤40 % (≤2.0 U/gHb) ≤50 % (≤2.5 U/gHb) ≤60 % (≤3.0 U/gHb)
Overall 400 2.3 (1–4) 8.3 (6–11) 9.5 (7–13) 10.3 (8–14) 11.3 (9–15) 12.0 (9–16)
Gender        
 Male 219 2.7 (1–6)** 11.4 (8–16) 12.8 (9–18) 13.2 (9–18) 13.7 (10–19)** 14.2 (10–19)**
 Female 181 1.7 (1–5) 4.4 (2–8) 5.5 (3–10) 6.6 (4–11) 8.3 (5–13) 9.4 (6–15)
District of residence        
 Al Marawi’ah 259 1.2 (0–3) 5.4 (3–9) 6.6 (4–10) 7.7 (5–12) 8.9 (6–13) 9.3 (6–13)
 Ad Durayhimi 141 4.3 (2–9)# 13.0 (9–20) 14.9 (10–22) 14.9 (10–22) 16.6 (11–22) 17.0 (12–24)
Consanguinity between parents        
 Yes 157 4.5 (2–9) 13.4 (9–20) 14.0 (9–20) 14.0 (9–20)# 15.9 (11–22) 17.2 (12–24)
 No 243 0.8 (0–3) 4.9 (3–8) 6.6 (4–10) 7.8 (5–12) 8.2 (5–12) 8.6 (6–13)
  1. G6PD glucose-6-phosphate dehydrogenase, CI confidence interval, U/gHb units per gram haemoglobin
  2. ** p > 0.05; # p = 0.05; p < 0.05 for all other differences
  3. aCalculated from the median value of 5.0 that is equivalent to 100 % activity