Fig. 1
Outline of mathematical equations defining the OptiMal-PK model. Schematic visualising differential equations which define the pharmacokinetics of a drug where it is absorbed from X1 (Gut) to X2 (Blood) at a rate of k a and eliminated at a rate of k e . Drug conc. is calculated at every time point as X2/volume of distribution. Parasite growth and drug induced death is defined by the dynamics of X3