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Fig. 2 | Malaria Journal

Fig. 2

From: OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens

Fig. 2

Interface of the OptiMal-PK tool. a Shows the panels where the user could use slide bars and turning knobs to adjust the PK parameters (dose, dosing frequency, absorption rate, apparent elimination half-life and clearance/F) and the PD parameters (Drug Potency) such as parasite reduction ratio (PRR), IC50, Mwt (to adjust for units of IC50 (moles) and dose (mgs) and the Slope factor (Hill’s Constant). Infection Severity Panel where the user could adjust the initial parasite count as well as the parasite multiplication ratio and finally a panel where the user could add an extra drug from a list of built-in drugs or a new drug whose parameters could be adjusted by the user. b Shows the output section of the tool, where upon running the simulation, the number of days of treatment required to clear parasites at the chosen PK/PD parameters will flash green, while the numbers of days that won’t be sufficient will flash red

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