Table 2 PK and PD parameters of DSM265 as reported in the literature

Dose (mg)

200–400 mg

Absorption rate (ka)

N/A (assumed to be 1)

Elimination half-life (h)

130 h

Clearance (L/h/kg)

0.003 (allometrically scaled from rodents)

Parasite reduction ratio (PRR) (/48 h)

17

IC₅₀ (nM)

13

Molecular weight (Da)

402

Hill’s slope constant

~1 (extrapolated from graph)