Table 1 Characteristics of the patients included in the study
All N = 85 | Quinine/atovaquone–proguanil n = 34 | Dihydroartemisinin–piperaquine n = 51 | p value | |
|---|---|---|---|---|
Age (years); median | ||||
(IQR) | 32 (9) | 31.5 (8) | 33 (10) | 0.99 |
Gender | ||||
Male | 82 (96.5 %) | 32 (94.1 %) | 50 (98 %) | 0.56 |
Female | 3 (3.5 %) | 2 (5.9 %) | 1 (2 %) | |
Origin | ||||
Sub-Saharan Africa | 84 (98.8 %) | 34 (100 %) | 50 (98 %) | 0.49 |
Spain | 1 (1.2 %) | 0 | 1 (2 %) | |
Type of traveller | ||||
VFR | 80 (94.1 %) | 31 (91.2 %) | 49 (96 %) | 0.25 |
Recent arrival | 4 (4.7 %) | 3 (8.8 %) | 1 (2 %) | |
Expatriate | 1 (1.2 %) | 0 | 1 (2 %) | |
Hb on admission (g/dL) ± typical deviation (range) | 13.7 ± 1.5 (10.1–16.9) | 13.5 ± 1.5 (10.1–16.9) | 13.8 ± 1.4 (10.1–16.4) | 0.36 |
Hb day 7 (g/dL) ± typical deviation (range) | 13.08 ± 1.49 (10–16) | 12.65 ± 1.42 (10–15.5) | 13.37 ± 1.48 (10–16) | 0.03 |
Hb day 28 (g/dL) ± typical deviation (range) | 13.94 ± 1.34 (9.1–16.8) | 13.45 ± 1.38 (9.1–14.8) | 14.32 ± 1.2 (11.7–16.8) | 0.02 |
Total platelets ×103/µL; median (IQR) | 94 (60) | 93 (59) | 95 (81) | 0.93 |
Parasitaemia level (%) | ||||
<1 | 48 (56.5 %) | 18 (52.9 %) | 30 (58.8 %) | 0.22 |
1–2 | 26 (30.6 %) | 9 (26.5 %) | 17 (33.3 %) | |
>2–5 | 11 (12.9 %) | 7 (20.6 %) | 4 (7.8 %) | |
Time in which parasitaemia becomes negative. Hours; median (IQR)a | 24 (24) | 48 (48) | 24 (24) | <0.01 |
Period of hospitalization. Days; median (IQR) | 2.88 (1.88) | 3.96 (2.87) | 2.67 (1.08) | <0.001 |