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Table 3 Frequency of haplotypes and their association with levels of IgG antibodies against the PvAMA-1, PvDBP and PvMSP-119 proteins

From: Cytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-119 IgG antibody levels in a malaria-endemic area of the Brazilian Amazon

Haplotypes Frequency PvAMA-1 PvDBP PvMSP-119
RI estimation Difference
(95 % CI)
P value RI estimation Difference
(95 % CI)
P value RI estimation Difference
(95 % CI)
P value
TNF−1031/−308/−238
 T/G/G 0.606 1.76 Reference   4.01 Reference   4.35 Reference  
 C/G/G 0.201   −0.13 (−0.49 to 0.24) 0.50   1.86 (−0.15 to 3.86) 0.07   −0.62 (−1.75 to 0.52) 0.29
 T/A/G 0.127   −0.31 (−0.74 to 0.12) 0.15   −0.89 (−3.20 to 1.41) 0.45   −0.58 (−1.88 to 0.73) 0.39
 C/G/A 0.041   −0.07 (−0.78 to 0.63) 0.84   −1.51 −5.17 to 2.15) 0.42   0.19 (−1.99 to 2.36) 0.86
IL10−819/−592
 C/C 0.644 1.54 Reference   4.77 Reference   4.13 Reference  
 T/A 0.311   0.05 (−0.25 to 0.35) 0.74   −0.09 (−1.83 to 1.66) 0.92   −0.48 (−1.42 to 0.46) 0.32
 T/C 0.037   0.50 (−0.17 to 1.18) 0.14   −1.50 (−5.43 to 2.43) 0.45   1.34 (−0.75 to 3.44) 0.21
  1. The effects of each haplotype were relative to the most frequent haplotype, which was used as the reference
  2. Δ % indicates the relative change in antibody levels compared to reference haplotypes, with a confidence interval of 95 %