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Table 3 Documented clinical or laboratory symptoms of severe malaria, by age

From: Adherence to national guidelines for the diagnosis and management of severe malaria: a nationwide, cross-sectional survey in Malawi, 2012

Symptom <5 years ≥5 years p value
n % (95% CI) n % (95% CI)
Seizures* 118 23.8 (18.5–29.2) 51 14.2 (7.3–21.1) 0.026
Lethargy/Coma 74 15.1 (10.7–19.5) 65 15.5 (10.4–20.6) 0.91
Vomiting everything 24 4.4 (2.1–6.8) 17 3.1 (1.4–4.9) 0.39
Unable to eat* 38 7.4 (4.6–10.3) 19 5.0 (2.2–7.7) 0.18
Jaundice* 19 3.3 (1.0–5.6) 4 0.7 (0.0–1.6) 0.0059
Difficulty breathing* 61 12.3 (8.0–16.5) 24 4.4 (2.1–6.6) 0.0002
Difficulty urinating 6 1.1 (0.0–2.4) 5 1.1 (0.1–2.2) 0.98
Red urine 3 0.5 (0.0–1.2) 2 0.6 (0.0–1.5)
Easy bleeding/bruising 0 0 0 0
Abnormal mental status 14 2.5 (1.1–3.9) 22 4.3 (1.7–6.9) 0.19
Abnormal neurologic exam 11 2.2 (1.0–3.4) 13 2.8 (1.2–4.3) 0.56
Severe anaemia* 51 9.6 (4.9–14.2) 20 3.8 (1.8–5.7) 0.0004
At least one severe symptom 287 56.1 (47.8–64.3) 177 42.4 (30.8–54.1) 0.06
  1. p value determined by Rao–Scott Chi square
  2. * p < 0.05