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Table 3 Pfmdr1 N86Y and Pfcrt K76T distribution on day 0, 3 and day of recurrent infection

From: Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial

 

Treatment arm

AL+PQ

AL

P-value

Day 0

   

 Pfmdr1

N86

91 (85.8 %)

92 (85.9 %)

0.49

86Y

11 (10.4 %)

8 (7.5 %)

0.45

N86Y

4 (3.8 %)

7 (6.5 %)

0.54

 Pfcrt

K76

97 (95.1 %)

101 (98.1 %)

0.49

76T

1 (0.9 %)

0 (0 %)

0.71

K76T

4 (3.9 %)

2 (1.9 %)

0.44

Day 3

 Pfmdr1

N86

15 (65.2 %)

20 (76.9 %)

0.59

86Y

2 (8.6 %)

2 (7.7 %)

0.54

N86Y

6 (26.1 %)

4 (15.4 %)

0.48

 Pfcrt

K76

24 (85.7 %)

27 (96.4 %)

0.24

76T

2 (7.1 %)

0 (0 %)

0.6

K76T

2 (7.1 %)

1 (3.6 %)

0.6

Day of recurrent parasitaemia

 Pfmdr1

N86

2 (66.7 %)

6 (85.7 %)

0.28

86Y

0 (0 %)

0 (0 %)

N86Y

1 (33.3 %)

1 (14.3 %)

1.0

 Pfcrt

K76

2 (100 %)

4 (80 %)

0.68

76T

0 (0 %)

0 (0 %)

K76T

0 (0 %)

1 (20 %)

1.0