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Fig. 1 | Malaria Journal

Fig. 1

From: Diagnosis and treatment based on quantitative PCR after controlled human malaria infection

Fig. 1

Parasitaemia at different thresholds of qPCR and association with adverse events. a Mean parasitaemia by qPCR from a total of 55 malaria naïve volunteers undergoing CHMI by five NF54 infected mosquito bites in nine trials. b Day of positive thick smear or positive qPCR at different parasite density thresholds as starting day of curative treatment. Box-and-whisker plots show the median, first and third quartiles and 5–95th percentiles. Numbers above the x-axis are median treatment days. c The mean number of adverse events per volunteer occurring prior to and after treatment. Gray total adverse events, Black grade 3. d The mean number of adverse events per volunteer occurring prior to thick smear positivity compared to different parasite thresholds for initiation of treatment. Percentages above the bars show the percentage of total AEs that occur relative to thick smear. Black grade 3, dark gray grade 2, light gray grade 1

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