From: Diagnosis and treatment based on quantitative PCR after controlled human malaria infection
Year | Number of volunteers | CPS-immunization | Patent parasitemia | Pre-patent perioda | References | ||
---|---|---|---|---|---|---|---|
Median | Range | ||||||
Study 1 | 2007 | 10 | 3 × 12–15 mosquitoes | 0/10 | – | – | Roestenberg et al. [13] |
5 | – | 5/5 | 9 | 7–10.5 | |||
Study 2b | 2007 | 18 | – | 18/18 | 10.5 | 9–12.5 | |
Study 3 | 2009 | 6 | 3 × 12–15 mosquitoesc | 2/6 | 16.8 | 15–18.6 | Roestenberg et al. [14] |
4 | – | 4/4 | 8.5 | 7.5–10.5 | |||
Study 4 | 2010 | 5 | – | 4/5 | 10.6 | 10.6–11 | Teirlinck et al. [15] |
Study 5 | 2011 | 5 | 3 × 15 mosquitoes | 1/5 | 12 | – | Bijker et al. [12] |
9 | 3 × 10 mosquitoes | 1/9 | 12 | – | |||
10 | 3 × 5 mosquitoes | 5/10 | 11 | 9–15 | |||
5 | – | 5/5 | 9.5 | 9–13.5 | |||
Study 6 | 2011 | 5 | 3 × 15 mosquitoes | 0/5 | – | – | Bijker et al. [10] |
5 | – | 5/5 | 12.5 | 9.5–12.5 | |||
Study 7 | 2012 | 15 | 3 × 8 mosquitoes | 5/15 | 12 | 11–14 | Bijker et al. [11] |
4 | – | 4/4 | 8.5 | 7–12 | |||
Study 8 | 2012 | 5 | – | 5/5 | 10.5 | 9–10.5 | |
Study 9 | 2012 | 5 | – | 5/5 | 12 | 10.5–16 | Bastiaens et al. [9] |