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Fig. 3 | Malaria Journal

Fig. 3

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Fig. 3

Mean drug concentration and anti—P. falciparum activity-time profiles. Drug concentration–time profiles (PK) measured by HPLC-ECD and anti-malarial activities-time profiles (ePD) simultaneously measured by ex vivo bioassay against P. falciparum W2 clone following equimolar 20 µmol kg−1 dose of a IV AL 11.8 mg kg−1, n = 8 and b IV AS 8.0 mg kg−1, n = 10 [reproduced from Fig. 5c (14)] in plasma of P. coatneyi infected rhesus monkeys. Top panel showed the parent drugs, their metabolites, combined parent and its metabolite, and anti-malarial activities of each parenteral regimen. Bottom panel showed direct comparison of c parent drugs (AL vs AS), d their metabolites (OHAL vs DHA), e combined parent + metabolite (AL + OHAL vs AS + DHA), and f their anti-malarial activities (IV AL vs IV AS). Values are mean ± 95 % CI

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Malaria Journal

ISSN: 1475-2875

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