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Table 1 The initial status of the monkeys and in vivo pharmacodynamics, parasites clearance values

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Parameters Unit Rx Median 25th IQT 75th IQT pa
Monkey age Year IV AL 8 8 10 1.0
IV AS 9 7 12
Monkey weight kg IV AL 8.4 6.7 9.0 0.8
IV AS 7.7 6.9 8.7
Parasite densityb Count mL−1 IV AL 727,850 639,946 848,916 <0.001
IV AS 261,452 139,771 489,064
Parasites/erythrocyte (PE) % IV AL 12.0 11.3 12.7 <0.001
IV AS 6.60 4.23 6.83
Parasites clearance rate (PCR) Count min−1 IV AL 5.34 4.32 6.54 0.1
IV AS 4.13 3.69 5.28
Parasites clearance half-life (PCt1/2) Hr IV AL 7.79 6.36 9.63 0.1
IV AS 10.1 7.88 11.3
95 % Parasites clearance (PC95) Day IV AL 1.22 1.13 1.27 0.01
IV AS 0.847 0.557 1.03
99 % Parasites clearance (PC99) Day IV AL 2.03 1.89 2.08 0.3
IV AS 1.84 1.47 2.01
Parasites clearance (PCT)c Day IV AL None None None NA
IV AS 7.00 5.07 8.00
  1. aMann Whitney test
  2. bGeometric mean and 95 % confidence interval
  3. cConventional method