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Table 2 Pharmacokinetics of intravenous artelinate and artesunate in plasma from P. coatneyi infected rhesus monkeys

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Pharmacokinetics Rx Parent compound (P) Metabolite (M) M/P % AUC0–20
Parameter Unit Median 25th IQT 75th IQT pa Median 25th IQT 75th IQT pa AUC0–∞
C bmax mM IV AL 60.2 55.9 65.3 <0.0001 10.9 9.10 13.4 <0.0001 0.18  
IV AS 28.2 24.3 38.0 7.23 6.52 7.41   0.26  
t c1/2 min IV AL 28.2 25.8 35.4 <0.0001 42.2 33.2 47.6 0.02 1.50  
IV AS 3.47 3.09 5.15 31.1 25.0 34.5 8.97  
AUC d0–∞ mM min IV AL 3706 2845 4218 <0.0001 1260 944 1519 <0.0001 0.33  
IV AS 288 260 399 453 415 494 1.58  
AUC e0–20 mM min IV AL 925 849 1028 <0.0001 117 100 153 0.7   24.6
IV AS 288 253 394 116 107 122   97.0
Clf L kg−1 min−1 IV AL 5.60 4.85 7.88 <0.0001       
IV AS 72.3 52.4 79.9       
V gz L kg−1 IV AL 0.259 0.241 0.294 0.07       
IV AS 0.397 0.311 0.507       
  1. aMann Whitney Test
  2. b C max maximum concentration of drug reached in plasma
  3. c t 1/2 elimination half-life
  4. d AUC 0–∞ area under the concentration–time curve from zero to infinity
  5. e AUC 0–20 area under the concentration–time curve from zero to 20 min
  6. f Cl apparent total body clearance
  7. g V z volume of distribution