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Table 3 Pharmacokinetic parameters based on combined parent drug and metabolite levels and ex vivo pharmacodynamics (ePD)

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Pharmacokinetics Rx Ex vivo pharmacodynamica Combined P + M Ex vivo potency % AUC0–20
Parameter Unit Median 25th IQT 75th IQT pb Median 25th IQT 75th IQT pb ePD/PK AS/AL AUC0–∞
C cmax mM IV
AL
7.76 7.09 8.13 <0.001 64.6 62.7 68.5 <0.001 0.120   
IV
AS
20.7 15.3 30.5 35.2 31.3 44.4 0.587 4.89  
t d1/2 min IV
AL
29.6 26.3 38.0 0.7 36.3 30.6 44.8 0.02 0.815   
IV
AS
29.9 23.4 33.2 29.1 23.7 31.4 1.028 1.26  
AUC e0–∞ mM min IV
AL
426 365 521 0.8 4911 3997 5827 <0.001 0.088   
IV
AS
485 297 586 764 698 926 0.643 7.31  
AUC f0–20 mM min IV
AL
115 109 121 <0.001 1051 1007 1107 <0.001 0.110   21.4
IV
AS
242 172 348 404 373 502 0.598 5.44 52.9
Clg L kg−1 min−1 IV
AL
48.5 39.5 57.0 0.83  
IV
AS
43.0 35.7 70.6
V hz L kg−1 IV
AL
2.14 1.91 2.32 0.57  
IV
AS
1.84 1.41 2.87
  1. aConcentration reported as DHA equivalents
  2. bMann Whitney Test
  3. c C max maximum concentration of drug reached in plasma
  4. d t 1/2 elimination half-life
  5. e AUC 0–∞ area under the concentration–time curve from zero to infinity
  6. f AUC 0–20 area under the concentration–time curve from zero to 20 min
  7. g Cl apparent total body clearance
  8. h V z volume of distribution