Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Table 3 Pharmacokinetic parameters based on combined parent drug and metabolite levels and ex vivo pharmacodynamics (ePD)

Pharmacokinetics		Rx	Ex vivo pharmacodynamic^a				Combined P + M				Ex vivo potency		% AUC_0–20
Parameter	Unit	Rx	Median	25th IQT	75th IQT	p^b	Median	25th IQT	75th IQT	p^b	ePD/PK	AS/AL	AUC_0–∞
C ^c_max	mM	IV AL	7.76	7.09	8.13	<0.001	64.6	62.7	68.5	<0.001	0.120
C ^c_max	mM	IV AS	20.7	15.3	30.5	<0.001	35.2	31.3	44.4	<0.001	0.587	4.89
t ^d_1/2	min	IV AL	29.6	26.3	38.0	0.7	36.3	30.6	44.8	0.02	0.815
t ^d_1/2	min	IV AS	29.9	23.4	33.2	0.7	29.1	23.7	31.4	0.02	1.028	1.26
AUC ^e_0–∞	mM min	IV AL	426	365	521	0.8	4911	3997	5827	<0.001	0.088
AUC ^e_0–∞	mM min	IV AS	485	297	586	0.8	764	698	926	<0.001	0.643	7.31
AUC ^f_0–20	mM min	IV AL	115	109	121	<0.001	1051	1007	1107	<0.001	0.110		21.4
AUC ^f_0–20	mM min	IV AS	242	172	348	<0.001	404	373	502	<0.001	0.598	5.44	52.9
Cl^g	L kg⁻¹ min⁻¹	IV AL	48.5	39.5	57.0	0.83
Cl^g	L kg⁻¹ min⁻¹	IV AS	43.0	35.7	70.6	0.83
V ^h_z	L kg⁻¹	IV AL	2.14	1.91	2.32	0.57
V ^h_z	L kg⁻¹	IV AS	1.84	1.41	2.87	0.57

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