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Table 4 Correlation between PK and ePD

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

PK-ePD linear regression IV AL IV AS
Parameter Analyte a b r2 p a b rp p
Cmax (mM) Parent      1.04 7.45 0.807 <0.001
t1/2 (min) Parent 0.69 7.89 0.964 <0.001     
Metabolite      0.72 9.09 0.743 0.001
AUC0–∞ (mM min) Parent 7.88 124 0.951 <0.001     
Combined      1.12 265 0.847 <0.001
AUC0–20 (mM min) Parent 8.09 32.7 0.751 0.005 0.94 76.3 0.803 <0.001
  1. PK = a*ePD + b