Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Table 5 Linear regression analyses between PK or ePD and iPD

Treatment	Compound	PK (ePD)	Unit	iPD	Unit	r²	p	a	b
IV AS	AS	V_z	mL kg⁻¹	PCt_1/2	h	0.724	0.002	48.5	−57.2
		C_max	mM	PCR	min	0.596	0.009	4.83	8.45
		Cl	L kg⁻¹ min⁻¹	PCT	Day	0.534	0.02	12.5	−12.2
	DHA	AUC_0–∞	mM min	PCt_1/2	h	0.709	0.002	−32.0	767
		AUC_0–∞	mM min	PCT	Day	0.608	0.008	−48.9	780
		t_1/2	min	PCR	min	0.576	0.01	2.30	19.3
	AS + DHA	t_1/2	min	PCt_1/2	h	0.772	0.0008	−1.30	40.6
		C_max	mM	PCR	min	0.619	0.007	5.09	14.0
		AUC_0–∞	mM min	PCT	Day	0.596	0.009	−98.5	1487
	BA	Cl	L kg⁻¹ min⁻¹	PCt_1/2	h	0.571	0.01	5.69	−4.08
		AUC _{0 –∞}	mM min	PCR	min	0.516	0.02	87.6	71.1
IV AL	BA	C _max	mM	PCt_1/2	h	0.615	0.04	0.447	11.0
		C _max	mM	PCR	min	0.611	0.04	0.665	3.82

\( {\text{PK}} = {\text{a}} * {\text{iPD}} + {\text{b}}, \) or \( {\text{ePD}} = {\text{a}} * {\text{iPD}} + {\text{b}} \)

ISSN: 1475-2875