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Table 5 Linear regression analyses between PK or ePD and iPD

From: Comparative pharmacokinetics and pharmacodynamics of intravenous artelinate versus artesunate in uncomplicated Plasmodium coatneyi-infected rhesus monkey model

Treatment Compound PK (ePD) Unit iPD Unit r2 p a b
IV AS AS Vz mL kg−1 PCt1/2 h 0.724 0.002 48.5 −57.2
   Cmax mM PCR min 0.596 0.009 4.83 8.45
   Cl L kg−1 min−1 PCT Day 0.534 0.02 12.5 −12.2
  DHA AUC0–∞ mM min PCt1/2 h 0.709 0.002 −32.0 767
   AUC0–∞ mM min PCT Day 0.608 0.008 −48.9 780
   t1/2 min PCR min 0.576 0.01 2.30 19.3
  AS + DHA t1/2 min PCt1/2 h 0.772 0.0008 −1.30 40.6
   Cmax mM PCR min 0.619 0.007 5.09 14.0
   AUC0–∞ mM min PCT Day 0.596 0.009 −98.5 1487
  BA Cl L kg−1 min−1 PCt1/2 h 0.571 0.01 5.69 −4.08
   AUC 0 –∞ mM min PCR min 0.516 0.02 87.6 71.1
IV AL BA C max mM PCt1/2 h 0.615 0.04 0.447 11.0
   C max mM PCR min 0.611 0.04 0.665 3.82
  1. \( {\text{PK}} = {\text{a}} * {\text{iPD}} + {\text{b}}, \) or \( {\text{ePD}} = {\text{a}} * {\text{iPD}} + {\text{b}} \)