Fig. 7

Comparison of fits and predictions of the two mechanistic hypotheses regarding the removal of uninfected RBCs, namely the age-independent model and the increased senescence model. a The time course of biotinylated RBCs predicted by each model (blue line age-independent model and red line increased senescence model), superimposed on the experimental results (circles) by Moreno et al. [14]. b Exhibits the time courses of the median ages of the RBC populations, predicted by each model (blue line age-independent model and red line increased rate of senescence model). The shaded areas highlight the 25th and 75th percentiles of the age distributions of each RBC population. The light gray line highlights the time course of parasitaemia, and the dark grey line exhibits the time course for the erythropoietic output as predicted for the age-independent model. c The haemoglobin time courses predicted by each model (blue line age-independent model and red line increased senescence model), along with experimental results (circles) by Moreno et al. [14]. d Exhibits the age-distributions of RBC populations for the age-independent model (blue line) and for the increased senescence model (red line) at day 9, which corresponds to the highest parasitaemia level (see panel b). For comparisons, the age-distribution of a healthy RBC population (green line) which corresponds to the initial state (day 0) of both models, is also shown