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Table 1 Baseline characteristics at enrolment

From: Phase 1 randomized controlled trial to evaluate the safety and immunogenicity of recombinant Pichia pastoris-expressed Plasmodium falciparum apical membrane antigen 1 (PfAMA1-FVO [25-545]) in healthy Malian adults in Bandiagara

Characteristics

PfAMA1

N = 20

Tetanus toxoid

N = 20

p value

Mean age in year ± SD

30.1 ± 10.6

26 ± 10.5

ns

Female (%)

70

65

ns

Mean WBC 103/µL ± SD

6.0 ± 1.3

6.4 ± 1.4

ns

Mean RBC 103/µL ± SD

4.6 ± 6

4.7 ± .4

ns

Mean Hemoglobin ± SD

13.3 ± 1.8

13.0 ± 1.2

ns

Mean Platelets103/µL ± SD

245.2 ± 64.8

255.2 ± 76.0

ns

Mean Lymphocytes 103/µL ± SD

2.6 ± 0.6

2.9 ± 0.8

ns

Mean Creatinin µM/l ± SD

62.7 ± 13.8

53.3 ± 5.5

ns

Mean ALT U/L ± SD

14.5 ± 5.5

12.7 ± 5.6

ns

GMT anti-AMA1 antibody titre

(95 % CI)

5164

(2494–10,691)

9938

(4484–22,025)

ns

  1. GMT geometric mean titre in arbitrary units (AU), CI confidence interval, ALT alanine Amino-transferase, SD standard deviation