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Fig. 1 | Malaria Journal

Fig. 1

From: Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections

Fig. 1

Study design, parasitaemias and treatment regimens of rhesus macaques infected with Plasmodium cynomolgi sporozoites. a Longitudinal study design to collect whole blood and bone marrow aspirates for current and retrospective analyses at critical infection points as indicated (yellow). b Log10 parasitaemia and treatment regimens for the five rhesus macaques infected with 2000 P. cynomolgi B strain sporozoites on day 0 are shown. Whole blood and bone marrow aspirate sample collections are marked in yellow for each animal and correspond with critical infection points depicted in Panel a and summarized in Table 1. Sub-curative and curative blood-stage treatments were administered as needed based on the clinical complications that occurred during the primary infection and to ensure bona fide relapses. c The mean of the peak parasitaemias for the primary and first relapses of RIc14, RSb14, RMe14, and RFa14 are shown. Statistical significance was assessed by a Wilcoxon-Matched pairs sign rank test; p-values less than 0.05 were considered significant

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