Fig. 4

Plasmodium cynomolgi B strain infection results in thrombocytopenia during the acute primary infection. a The mean platelet concentrations before infection, during the acute primary, and post peak of parasitemia are shown. b Parasitemia in relation to platelet concentration is shown for each macaque. Orange bars indicate when peripheral blood and bone marrow aspirates were collected for retrospective systems biology analysis. c Parasitemia in relation to the percent of pre-infection platelet values is shown. d The mean platelet volume in relation to the platelet concentration is shown. Statistical analysis was performed by a Friedman's Test with Dunn's multiple comparison post-hoc for panel a and no statistical significance was found