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Table 1 Criteria for the collection of samples at different experimental periods

From: Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections

Experimental period

Criteriaa

Pre-infection

Normal motor activity and appetite

Haematological parameters within normal range

Acute primary

Prostration, lethargy, low appetite

Moderate to severe anaemia, thrombocytopaenia, tachypnea, hyperparasitaemia, impaired consciousness, hyperpyrexia, azotemia, hyponatremia, hyperkalaemia and clinical evidence of activated coagulation (e.g., petechiae)

Post peak

Moderate anaemia, reticulocytemia, control of parasitaemia

Relapse

Low parasitaemia

Inter-relapse

Haematological parameters within normal range, no parasitaemia

Final

Haematological parameters within normal range

  1. aThe specific criteria and observations at sample collection points during the infection were recorded for each animal based on the clinical assessments made by veterinary staff and investigators