Table 1 Ex vivo susceptibility of Plasmodium falciparum isolates from Thiès in 2012 and 2013
Drug | 2012 | 2013 | p value | ||||||
|---|---|---|---|---|---|---|---|---|---|
3D7 IC50 (nM) | Mean with 95 % IC (nM) | Range (nM) | 3D7 IC50 (nM) | Mean with 95 % IC (nM) | Range (nM) | ||||
Min | Max | ||||||||
Min | Max | ||||||||
AMQ | 5.488 | 13.84 (11.84–16.13) | 0.7425 | 63.13 | 3.321 | 6.484 (5.208–8.071) | 1.925 | 43.85 | <0.0001 |
LUM | 417.5 | 173.4 (142.0–211.8) | 21.26 | 981.1 | 164.3 | 113.2 (85.9–149.1) | 17.05 | 414 | 0.01 |
ARS | 17.88 | 3.322 (2.852–3.869) | 0.5222 | 10.16 | 2.805 | 3.673 (3.046–4.428) | 1.22 | 18.54 | 0.34 |
AMT | – | – | – | 7 | 6.222 (5.013–7.724) | 1.188 | 33.6 | – | |
CQ | 17.58 | 39.72 (30.92–51.02) | 2.850 | 402.9 | 9.287 | 18.29 (29.07–87.59) | 6.474 | 384.1 | <0.0001 |