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Table 3 Descriptive statistics of diagnostic accuracy of various biomarker measurements at presentation for the presence or subsequent development of acute kidney injury (AKI)

From: Neutrophil gelatinase-associated lipocalin (NGAL) predicts the occurrence of malaria-induced acute kidney injury

Parameter and cut-off value Sensitivity Specificity PPV NPV Youden index AUROC P value*
sCreatinine ≥ 128 µmol/L 0.83 (0.36–1.00) 0.97 (0.84–1.00) 0.83 (0.36–0.99) 0.97 (0.84–1.00) 0.80 0.85 (0.60–1.00)  
sNGAL ≥ 168 ng/ml 1.00 (0.54–1.00) 0.88 (0.72–0.97) 0.60 (0.26–0.88) 1.00 (0.88–1.00) 0.88 0.98 (0.93–1.0) 0.389
uNGAL ≥ 308 ng/ml 1.00 (0.54–1.00) 1.00 (0.89–1.00) 1.00 (0.54–1.00) 1.00 (0.89–1.00) 1.00 1.00 (1.00–1.00) 0.299
uNGAL/sNGAL ≥ 1.9 0.83 (0.36–1.00) 0.97 (0.84–1.00) 0.83 (0.36–1.00) 0.96 (0.84–1.00) 0.80 0.95 (0.85–1.00) 0.544
uNGAL/uCreat ≥ 5.1 ng/mmol 1.00 (0.54–1.00) 0.88 (0.72–0.97) 0.60 (0.26–0.88) 1.00 (0.88–1.00) 0.88 0.98 (0.93–1.00) 0.390
uKIM-1 ≥ 1.83 ng/ml 1.00 (0.54–1.00) 0.72 (0.54–0.87) 0.40 (0.16–0.68) 1.00 (0.86–1.00) 0.72 0.87 (0.75–0.99) 0.919
uKIM-1 /uCreat ≤ 0.085 ng/mmol 1.00 (0.54–1.00) 0.58 (0.39–0.74) 0.30 (0.12–0.54) 1.00 (0.82–1.00) 0.58 0.76 (0.61–0.92) 0.810
  1. Data are given as mean (95 % confidence interval)
  2. Optimal cut-off values were determined using the Youden index
  3. PPV positive predictive value; NPV negative predictive value; AUROC area under the ROC curve
  4. * P values of pair-wise comparison of AUROCs are given (with creatinine ROC curve as comparator)