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Fig. 2 | Malaria Journal

Fig. 2

From: Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Fig. 2

Hypoxia-induced sickling of uninfected and Plasmodium falciparum (FUP line) ring-infected RBCs. a Mean sickling rates (± SEM) in uninfected HbAS (n = 5) and HbSS RBCs (n = 3) exposed to ‘stringent’ hypoxia (0.5 % O2, 5 % CO2, 94.5 % N2) (left y-axis), and partial pressures of O2 and CO2 (right y-axis) measurements over 45 min. b Morphologies of uninfected RBCs and ring-infected RBCs (iRBCs) exposed to stringent hypoxia: discoid RBC (1), sickled RBC (2), indeterminate RBC (3), discoid iRBC (4), sickled iRBC (5) and indeterminate iRBC (6). c Mean sickling rates (± SEM) of uninfected and ring-infected HbAS and HbSS RBCs exposed to stringent hypoxia for 45 min. RBC morphology was determined by microscopy. d Correlation between mean sickling rates obtained using two RBC morphology counting methods, microscopy and imaging flow cytometry. The haemoglobin type and infection status of each sample is shown

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