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Table 3 Performances and differences in performances among study sites and RDTs

From: Performance and time to become negative after treatment of three malaria rapid diagnostic tests in low and high malaria transmission settings

Test parameter

Site

SD Bioline HRP2

CareStart HRP2

CareStart pLDH

SD Bioline HRP2 vs CareStart HRP2

SD Bioline HRP2 vs CareStart pLDH

CareStart HRP2 vs CareStart pLDH

%

[95 % CI]

%

[95 % CI]

%

[95 % CI]

Diff %

[95 % CI]

Diff  %

[95 % CI]

Diff  %

[95 % CI]

Sensitivity

Mbarara

98.4

[96.0 to 99.6]

98.8

[96.6 to 99.8]

96.1

[92.9 to 98.1]

−0.4

[−1.5 to 0.8]

2.3

[−0.2 to 4.9]

2.7

[0.3 to 5.1]*

Kazo

99.2

[97.3 to 99.9]

98.9

[96.7 to 99.8]

94.7

[91.2 to 97.0]

0.4

[−0.7 to 1.5]

4.6

[1.7 to 7.5]***

4.2

[1.2 to 7.2]**

Diff

−0.8

[−2.6 to 1.0]

0.0

[−1.9 to 1.8]

1.4

[−2.2 to 5.0]

      

Specificity

Mbarara

98.9

[98.5 to 99.2]

98.8

[98.5 to 99.1]

99.8

[99.6 to 99.9]

0.0

[−0.1 to 0.2]

−0.9

[−1.2 to −0.6]***

−0.9

[−1.2 to −0.6]***

Kazo

79.7

[73.4 to 85.1]

80.7

[74.5 to 86.0]

93.9

[89.6 to 96.8]

−1.0

[−2.9 to 0.9]

−14.2

[−19.8 to −8.6]***

−13.2

[−18.6 to −7.8]***

Diff

19.2

[13.6 to 24.8]$$$

18.1

[12.6 to 23.6]$$$

5.8

[2.5 to 9.2]$$$

      

Misclassification

Mbarara

1.1

[0.9 to 1.5]

1.2

[0.9 to 1.5]

0.4

[0.3 to 0.7]

0.0

[−0.1 to 0.1]

0.7

[0.4 to 1.0]***

0.7

[0.4 to 1.0]***

Kazo

9.2

[6.7 to 12.2]

8.9

[6.5 to 11.9]

5.7

[3.7 to 8.2]

0.2

[−0.7 to 1.2]

3.5

[0.5 to 6.5]*

3.3

[0.3 to 6.2]*

Diff

−8.0

[−10.7 to −5.4]$$$

−7.8

[−10.4 to −5.1]$$$

−5.2

[−7.4 to −3.1]$$$

      

Positive predictive value

Mbarara

83.2

[78.5 to 87.2]

82.7

[70.0 to 86.7]

95.7

[92.5 to 97.8]

–

 

–

 

–

 

Kazo

86.7

[82.3 to 90.3]

87.2

[82.9 to 90.8]

95.4

[92.1 to 97.6]

–

 

–

 

–

 

Diff

−3.5

[−9.2 to 2.2]

−4.5

[−10.2 to 1.2]

0.3

[−3.2 to 3.9]

      

Negative predictive value

Mbarara

99.9

[99.8 to 100.0]

99.9

[99.8 to 100.0]

99.8

[99.6 to 99.9]

–

 

–

 

–

 

Kazo

98.7

[95.5 to 99.8]

98.1

[94.7 to 99.6]

93.0

[88.5 to 96.1]

–

 

–

 

–

 

Diff

1.2

[−0.6 to 2.9]$

1.8

[−0.3 to 3.9]$

6.8

[3.3 to 10.4]$$$

      
  1. * Exact McNemar’s p value <0.05
  2. ** Exact McNemar’s p value <0.01
  3. *** Exact McNemar’s p value <0.001
  4. $ Fisher’s exact p value <0.05
  5. $$ Fisher’s exact p value <0.01
  6. $$$ Fisher’s exact p value <0.001
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Malaria Journal

ISSN: 1475-2875

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