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Table 1 Inhibitory activity of hexane bark extract of Z. heitzii and pure compounds isolated from the extract against P. falciparum in 72 h assays

From: Natural products from Zanthoxylum heitzii with potent activity against the malaria parasite

  IC50 IC50
(μg/ml) (µM)
Hexane bark extract 0.050 ± 0.004 N/A
Dihydronitidine 0.0089 ± 0.0008 0.025 ± 0.002
Pellitorine 1.96 ± 0.12 8.8 ± 0.5
Heitziquinone 3.55 ± 0.62 9.7 ± 1.6
Sesamin >10 >28
Isobauerenol >10 >23
Caryophyllene oxide >10 >49
Rhoifoline B >10 >28
Isoarnottianamide >10 >26
Nitidinea 0.038 ± 0.002 0.099 ± 0.050
WR 99210a 3.167 × 10−6 1.2 × 10−5
  1. Results ± SEM from three biological replicates using 3D7 parasites are shown
  2. aPositive control