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Table 1 Severity criteria for severe malaria

From: Factors associated with the severity and complication of patients with malaria hospitalized between 2009 and 2013 in three municipalities of Colombia, case control study

Clinical criteria Laboratory criteria
Loss of consciousness or profound coma Haemoglobinuria
Prostration; extreme weakness with inability to walk or sit without assistance Hypoglycaemia (<60 mg/dL)
Inability to feed oneself Metabolic acidosis (plasmatic bicarbonate <15 mmol/L)
Multiple seizures; more than 1 episode in 24 h Hyperlactaemia (lactate acid <5 mmol/L)
Respiratory distress syndrome Severe anaemia (haemoglobin <7 g/dL, haematocrit <21 %)
Circulatory collapse/shock; systolic arterial pressure <80 mmHg in adults and <50 mmHg in children Hyperparasitaemia (>50,000 asexual parasites/μL) with the diagnosis of P. falciparum, or mixed infection with P. vivax
Clinical jaundice with signs of vital organ failure Thrombocytopaenia (<50,000 mm3)
Spontaneous haemorrhage Elevated transaminase (>80 IU)*
Pulmonary oedema evidenced through radiography Elevated total bilirubin (>1.5 mg/dL)
Renal insufficiency (serum creatinine level >1.5 mg/dL)
  1. * Elevated transaminases >80 UI was the criteria used in this study; which differs from the OMS guideline of transaminases three times the normal range and the Colombian Guideline of transaminases >40 UI