Exceptionally long-range haplotypes in Plasmodium falciparum chromosome 6 maintained in an endemic African population

Table 1 Frequencies of core haplotypes spanning 71.5 kb across the selective sweep region on chromosome 6 of P. falciparum from the Gambia collected in 1984, 1991, 2008 and 2014

Haplotype	1984	1991	2008	2014	Frequency
274 190 271 142 197		4	28	25	13.0
280 181 277 144 197			7	6	3.0
274 190 271 144 197		1	7	1	2.1
274 190 275 144 197				8	1.8
280 181 279 142 197			6	1	1.6
274 181 269 142 197		1	5		1.4
274 181 271 142 197		1	3	2	1.4
274 181 281 138 225			3	2	1.1
274 184 285 126 197		1	2	2	1.1
274 181 269 140 197			4		0.9
274 181 285 138 197		1		3	0.9
280 181 279 144 197			1	3	0.9
280 184 271 142 197			4		0.9
268 178 271 142 197			1	2	0.7
274 178 275 144 197				3	0.7
274 178 279 128 213		1	2		0.7
274 181 273 136 197	2		1		0.7
274 181 279 142 197			3		0.7
274 190 275 144 205				3	0.7
280 184 285 142 197			2	1	0.7
298 178 275 144 197				3	0.7
268 181 265 144 197			2		0.5
274 172 271 142 197				2	0.5
274 175 271 150 197	1	1			0.5
274 178 277 144 221			2		0.5
274 181 269 144 197			2		0.5
274 181 271 128 201	2				0.5
274 181 271 138 197			2		0.5
274 181 271 146 197		1	1		0.5
274 181 275 150 197			2		0.5
274 181 275 154 213				2	0.5
274 181 281 138 197			2		0.5
274 181 291 132 225			2		0.5
274 184 283 126 197			1	1	0.5
274 184 283 138 229			2		0.5
274 190 269 142 197			2		0.5
274 190 271 142 217				2	0.5
274 190 277 144 197			1	1	0.5
280 181 271 142 197		1		1	0.5
280 181 277 142 197				2	0.5
280 181 281 142 197			1	1	0.5

The first column shows the haplotypes defined by a contiguous string of PCR fragment sizes in base pairs for five neighbouring loci within this region. The following columns show the number of isolates from each year with the haplotype. The last column presents the frequencies for the entire population

ISSN: 1475-2875