Fig. 4

Partial amino acid sequences of Plasmodium falciparum MSP-3. a Alignment of the deduced amino acid sequences encoding the AHRs, revealing seven sequence variants. Dimorphic and trimorphic amino acid residues are highlighted in grey and green, respectively. Variants 1 and 7 are identical to the MSP-3 sequences of the P. falciparum reference strains 3D7 and K1, respectively. Two haplotypes (H1 and H2) of the 3D7 allele encode variants 1 and 2, while the other five haplotypes encode variants 3–7. Note that haplotypes 6A and 6B encode the same amino acid sequence (variant 6). b Location of the polymorphic amino acid residues in MSP-3 sequences. The positions of MSP-3 sequences are numbered after P. falciparum strain 3D7