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Fig. 3 | Malaria Journal

Fig. 3

From: Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand

Fig. 3

PPQ and MQ susceptibility of Cambodian and Thai isolates collected from 2010 to 2015. Panels a and b, respectively, present ex vivo P. falciparum IC50 and IC90 for PPQ, while MQ IC50 is shown in panel c. Site/year where samples were collected are indicated on the X-axis—Preah Vihear (PV), and Oddar MeanChey (OM) provinces of Cambodia, and Kwai River Christian Hospital (KRCH) in Kanchanaburi Province and Pursaron (PL) in Srisaket Province, Thailand, with median values of IC50 or IC90 denoted for each site/year with a black bar and indicated on X-axis. Red dotted lines indicate the PPQ susceptibility baseline of Cambodian isolates from 2010–2012 (a, b) and WHO values for suspected MQ resistance (c). The W2 susceptibility value is indicated by blue dashed lines. Isolates above prior year baseline for PPQ (IC50 > 69 nM, IC90 > 160 nM) are in red, with the proportion isolates above baseline indicated

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