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Table 2 Studies documenting population coverage only (n = 28, in chronological order)

From: Community engagement and population coverage in mass anti-malarial administrations: a systematic literature review

Author, year, country Epidemiology (baseline parasitemia) Study type and the context Anti-malarial Coverage/% Additional interventions
Kingsbury 1931, Malaysia [58] 28% (Malaria incidence had been high for many years in the rubber estate) Non-RCT
Plasmoquine was administered to all individuals living in rubber plantation and the control population was chosen from another rubber plantation estate. The population composed of labourers working in rubber industry and the considerable fluctuation of population was observed over the years
Plasmoquine 97 Larviciding
Kligler 1931, Palestine [59] 69.4% in children age 0–14 years old Before and after study carried out in 5 villages adjacent to Huleh marsh Plasmochine + quinine 80 NR
Gribben 1933, Trinidad and Tobago [28]   NR (259 cases treated during October–December 1931; and 96 cases treated during July 1932 Before and after study (compared malaria cases seeking treatment before MDA and after MDA) Plasmoquine + quinine 80 Lake draining and oiling
Henderson 1934, Sudan [29] NR. Heavily infected village Non-RCT. 160 members of an isolated community in Sudan (~1/2 of population) Quinoplasmine + plasmoquine 100 Larviciding
White 1934, India [60] 55% Non-RCT Children of age 0–10 years living in a railway settlement and an adjacent village were selected for both control and intervention Euquinine, plasmochin 94 Larviciding
Ray 1948, India [61] 0.7% in adults to 35% in children Before and after study conducted in tea estate in India Paludrine 75 IRS
Banerjea 1949, India [62] 4.37% Non-RCT. The study was conducted in rural west Bengal Proguanil 89 NR
Van Goor 1950(C), Indonesia [63] 26 5–40% Before and After study
Different study arms examining the efficacy of monotherapy mainly with varying prophylactic doses of proguanil (a small subgroup was given chloroquine). The goal was to establish an optimal dosing regimen
Proguanil and chloroquine 90 NR
Norman 1952, India [64] NR Descriptive
The chemoprophylaxis in Assam Valley tea estate populations (laborers and their families) was conducted for 6 months. Half of the populations did not take the medicine as evidenced in their examined urine
Proguanil 52 NR
Archibald 1956, Nigeria [65] 48.7% (5–10 years) Non-RCT
Children with 5–10 years age group were selected for the chemotherapy
Pyrimethamine 80 NR
Clyde 1958, Tanzania [66] 82.6% Before and after
Labourers on tea estate in eastern Usumbara Mountains
Pyrimethamine 82 IRS
Van Dijk 1958, Netherlands New Guinea (PNG) [67] 11.2% Before and after
Inhabitants of 30 villages in Demta district
Chloroquine 93 IRS with DDT
Afridi 1959, Pakistan [68] NR Non-RCT
Population at villages near Daur river in Hazara district of west Pakistan
Pyrimethamine 96 NR
Van Dijk 1961, Netherlands New Guinea (PNG) [69] 17.5% Before and after
Inhabitants of Inanwatan. Area is unstable hyperendemic
Chloroquine 97.2 NR
Metselaar 1961, Netherlands New Guinea [70] 12–28% Before and after
The population lived near lake Sentani and were likely to sleep in garden houses
Chloroquine + pyrimethamine 90 IRS with DDT
Ho 1965, China [71] NR Descriptive
Mass screen and treat study
Chloroquine + primaquine, pyrimethamine + primaquine 95 ND
Ossi 1967, Iraq [72] NR
Annual incidence of malaria cases 2221
Before and after
Chemoprophylaxis was conducted in Basrah city with the highest malaria incidence
Chloroquine + pyrimethamine 57 5 IRS with DDT
Singh 1968, India [73] 0.98 cases/1000/population/month Before and after
All people in 29 villages in Azamgarh but in subsequent rounds only targeted febrile cases, their contacts and housemates
Chloroquine, primaquine 72.7 IRS with DDT
Lakshmanacharyulu 1968, India [74] 56.3% Before and after
Labourers within a dam and canal project area previously not know to be malaria endemic
Chloroquine + pyrimethamine 80 IRS with DDT, larviciding
Onori 1972, Syria [75] Average monthly number of malaria cases: 46.6 Before and After
All individuals in Ghab Village
Chloroquine + pyrimethamine 85 IRS with DDT
Najera 1973, Nigeria [76] 19% Non-RCT
All villagers older than 3 months from Kankiya district in North Central State
Chloroquine + pyrimethamine 85.9 IRS with DDT
Schliessmann 1973, Haiti [77]   0.02/1000 population/month Descriptive
No details on drug or the regimen
Population of 3 localities within Section Rurale I Varreux
NR 40 IRS with DDT
Paik 1974a, British Soloman Islands [78] 27.8% Before and after study
Only children aged 2–9 years of north coastal areas of Nggela island group
Chloroquine + pyrimethamine 90 IRS with DDT
Paik 1974b, British Soloman Islands [78] 18/1000 population/month Before and after Study
Population of Gilbertese settlements in western district. Sleeping outdoor is common here
Chloroquine + primaquine 90 NR
Kondrashin 1985, India [79] In 1980: Pv: 3.4/1000pop/month and Pf: 1.9/1000pop/month Before and after
Inhabitants of 8 PHC (Primary Health Centre) catchment area in five malaria endemic districts of Andhra Pradesh
Chloroquine + primaquine 85 IRS
Strickland 1986, Pakistan [80] 24.9% Before and after
All individuals above age 3 years. Suspected cases of malaria were treated with chloroquine and individuals with parasitemia were treated with Sulfadoxine and Pyrimethamine
Sulfadoxine, pyrimethamine 67.3 NR
Hii 1987, Malaysia [81] 46.3–55.6% Before and after
The intervention intended to determine the effects of impregnated bed nets. Improver and lack of use and damage to the bed nets and reluctance of the population to take the drugs were noticed
SP + primaquine 81.6 ITNs
Babione 1996, Central America (multiple locations) [82] NR Descriptive
Field test in El Salvador. Population and intervention not well described
Chloroquine + primaquine 77.5 IRS with DDT, larviciding