Fig. 2
Interactions between the three mAbs (MAL1C, MAL2A, and MAL3B) and the CSP-derived peptides as measured by SPR. The data for the mAb:CSP-peptide interaction were measured in the format of a kinetic titration [30], with mAb as the ligand (i.e., coated onto the sensor surface) and either (NANP)6 (a) and R32LR (b) as the analyte. In both panels, the top graphs display the sensorgrams (black traces) and the fit to the data with a 1:1 Langmuir binding model (red traces). The residuals of the fit are shown in the bottom graph. The (apparent) affinity constants for the interactions and the chi2 of the fit are also shown for convenience. K D dissociation constant, K D, app apparent dissociation constant, s seconds, RU resonance units