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Table 4 Association between antibody tertiles at enrolment and small for gestational age and low length-for-age (LAZ <−2)

From: Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation

Antibody type

Small for gestational age

Low length-for-age (LAZ <−2)

Middle compared to low antibody tertile

High compared to low antibody tertile

Middle compared to low antibody tertile

High compared to low antibody tertile

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

IgG to placental-binding VSA

0.74 (0.42, 1.31)

0.301

0.91 (0.52,1.60)

0.736

1.27 (0.62, 2.62)

0.513

1.05 (0.50, 2.21)

0.894

Opsonising antibodies to placental-binding VSA

0.92 (0.54, 1.57)

0.757

0.78 (0.45, 1.35)

0.369

2.25 (1.14, 4.42)

0.019*

1.14 (0.53, 2.47)

0.734

Opsonising antibodies to non-placental-binding VSA

1.34 (0.79, 2.28)

0.282

1.17 (0.67, 2.02)

0.584

1.29 (0.65, 2.56)

0.465

1.13 (0.56, 2.28)

0.735

MSP1 19kD

1.21 (0.71, 2.05)

0.476

0.93 (0.55, 1.59)

0.795

1.05 (0.54, 2.02)

0.889

0.75 (0.38, 1.48)

0.408

MSP2

1.12 (0.66, 1.89)

0.671

0.82 (0.48, 1.42)

0.486

0.97 (0.50, 1.90)

0.930

0.96 (0.48, 1.93)

0.918

MSP3

1.28 (0.75, 2.18)

0.358

1.65 (0.98, 2.80)

0.060

0.87 (0.44, 1.72)

0.682

1.28 (0.67, 2.46)

0.459

EBA175

1.62 (0.94, 2.75)

0.081

1.45 (0.85, 2.45)

0.172

0.88 (0.45, 1.72)

0.711

0.84 (0.43, 1.62)

0.608

PfRh2

1.26 (0.75, 2.13)

0.378

1.01 (0.59, 1.72)

0.979

1.18 (0.61, 2.29)

0.620

0.92 (0.46, 1.84)

0.815

Schizont extract

1.25 (0.68, 2.28)

0.469

1.44 (0.80, 2.61)

0.226

1.15 (0.54, 2.44)

0.724

1.27 (0.61, 2.63)

0.518

  1. Data presented as odds ratio (95% confidence interval). Multivariate logistic regression analysis performed to determine the risk of giving birth to a child with SGA and LAZ <−2 among pregnant women in middle and high antibody tertile compared to women in the low antibody tertile. Analysis adjusted for gravidity, maternal age, HIV, bed net use, body mass index at enrolment, malaria microscopy at enrolment, socioeconomic status, study site, season at enrolment and supplementation groups
  2. LAZ, length-for-age z-score; OR, odds ratio; 95 % CI, 95% confidence interval; IgG, immunoglobulin G; VSA, variant surface antigens, MSP, merozoite surface protein; EBA175, erythrocyte binding homologue 175; PfRh2, Plasmodium falciparum reticulocyte binding homologue 2