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Table 4 Amino acids at the Dhfr-ts domain believed to affect antifolate binding

From: Parasitological correlates of Plasmodium ovale curtisi and Plasmodium ovale wallikeri infection

Plasmodium ovale isolate Amino acid number in Dhfr-ts domain relevant to antifolate binding
53 57 58 61 113 116 169 190 503 523
P. ovale curtisi KP050414.1
 2 ND ND ND ND ND ND I T ND ND
 4 ND F S T S S I T R C
 8 ND F S T S S I T R C
 9 ND F S T S S I T R C
 17 ND ND ND ND ND ND ND ND ND ND
 21 ND ND ND ND ND ND I T ND ND
 22 ND F S T S S I T R C
P. ovale curtisi EU266611 D F S T S S I T R C
P. ovale curtisi EU266608 D F S T S S I T R C
P. ovale curtisi EU266609 D F S T S S I T R C
P. ovale curtisi EU266610 D F S T S S I T R C
P. ovale curtisi EU266606 D F S T S S I T R C
P. ovale curtisi EU266607 D F S T S S I T R C
 23 ND ND ND ND S S I T R C
 24 D F S T S S I T R C
 26 ND F S T S S L T R C
 27 ND ND ND ND S S I T R C
 28 ND F S T S S I T R C
 29 ND ND ND ND S S I T R C
 30 D F S T S S I T R C
 33 ND F S T S S I T R C
 34 ND F S T S S I T R C
 35 D F S T S S I T R C
 37 D F S T S S I T R C
 39 ND F S T S S I T R C
 41 D F S T S S I T R C
 42 ND F S T S S I T R C
 43 ND ND ND ND S S I T R C
 44 ND ND ND ND S S I T R C
P. ovale wallikeri KP050415.1 D F S T S S I T R C
P. ovale wallikeri KP050409.1 D L R T S S I T R C
P. ovale wallikeri EU266612 D F S T S S I T R C
P. ovale wallikeri EU266613 D F S T S S I T R C
P. ovale wallikeri EU266614 D F S T S S I T R C
P. ovale wallikeri EU266615 D F S T S S I T R C
P. ovale wallikeri EU266617 D F S T S S I T R C
P. ovale wallikeri GQ250090 D F S T S S I T R C
P. ovale wallikeri EU266616 D F S T S S I T R C
P. ovale wallikeri EU266618 D F S T S S I T R C
P. ovale wallikeri GQ250091 D F S T S S I T R C
P. ovale wallikeri EU266601 D F S T S S I T R C
P. ovale wallikeri EU266604 D F S T S S I T R C
P. ovale wallikeri EU266603 D F S T S S I T R C
P. ovale wallikeri EU266605 D F S T S S I T R C
  1. ND not determined